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ERB-hRNase

ERB-hRNase - human anti-ErbB2 immunoRNase with erbicin fused to HP-RNase; consists of human pancreatic RNase fused to anti-ErbB2 scFv

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Recombinant Proteins: 2754
    - Recombinant Fusion Proteins: 333
      - ERB-hRNase: 2
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        ERB-hRNase: 2

Experts

1.	Borriello, Marianna: 1 article (06/2008)
2.	D'Alessio, Giuseppe: 1 article (06/2008)
3.	De Lorenzo, Claudia: 1 article (06/2008)
4.	Riccio, Gennaro: 1 article (06/2008)
5.	Cafaro, V: 1 article (11/2007)
6.	D'Alessio, G: 1 article (11/2007)
7.	De Lorenzo, C: 1 article (11/2007)
8.	Troise, F: 1 article (11/2007)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "This novel immunoagent with 2 scFv moieties each fused to 1 of the 2 subunits of the dimeric RNase, called ERB-HHP2-RNase, has shown improved biologic properties with respect to the previously reported monomeric ERB-hRNase immunoRNase: it selectively binds ErbB2-positive cancer cells with an increased avidity; it is not inhibited by the cytosolic ribonuclease inhibitor; it is endowed with a more powerful cytotoxic activity." 11/19/2007 - "Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. "
2.	Breast Neoplasms (Breast Cancer) 11/19/2007 - "In Erb-hRNase, Erbicin is linked to a human RNase and in Erb-hcAb it is linked to the key structural and functional regions of a human IgG. Herceptin is an anti-ErbB2 humanised antibody successfully used in the immunotherapy of breast cancer. "

Related Drugs and Biologics

1.	Ribonucleases (Ribonuclease)
2.	Immunoconjugates (Immunoconjugate)
3.	Immunoglobulin G (IgG)
4.	Trastuzumab (Herceptin)
5.	Erb-hcAb

Related Therapies and Procedures

1.	Immunotherapy