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cucurbitacin R

from Cayaponia tayuya roots; structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - cucurbitacin R: 3

Experts

1.	Cerdá-Nicolás, Miguel: 2 articles (02/2010 - 02/2007)
2.	Escandell, José M: 2 articles (02/2010 - 02/2007)
3.	Giner, Rosa M: 2 articles (02/2010 - 02/2007)
4.	Máñez, Salvador: 2 articles (02/2010 - 02/2007)
5.	Escandell, J M: 1 article (08/2010)
6.	Giner, R M: 1 article (08/2010)
7.	Máñez, S: 1 article (08/2010)
8.	Recio, M C: 1 article (08/2010)
9.	Ríos, J L: 1 article (08/2010)
10.	Merfort, Irmgard: 1 article (02/2010)

Related Diseases

1.	Arthritis (Polyarthritis) 02/01/2007 - "The aim of this study was to investigate the effects of cucurbitacin R on an experimental model of adjuvant-induced arthritis in rats. " 08/01/2010 - "Cucurbitacin R, a natural anti-inflammatory product, has been shown to exhibit activity against both adjuvant-induced arthritis and delayed-type hypersensitivity reactions induced by various agents. "
2.	Inflammation (Inflammations) 02/01/2010 - "Cucurbitacin R is known to exhibit an anti-inflammatory effect in different experimental models of inflammation. " 02/01/2007 - "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages."
3.	Hypersensitivity (Allergy) 08/01/2010 - "Cucurbitacin R, a natural anti-inflammatory product, has been shown to exhibit activity against both adjuvant-induced arthritis and delayed-type hypersensitivity reactions induced by various agents. " 02/01/2010 - "In this article, we outline the effect of cucurbitacin R on T lymphocyte proliferation, cytokine production, and nuclear factor activation, as well as its influence on various experimental models of delayed-type hypersensitivity (DTH) in mice. " 02/01/2010 - "Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus."
4.	Edema (Dropsy) 02/01/2010 - "Although cucurbitacin R was found to reduce the inflammatory response brought on by both oxazolone and dinitrofluorobenzene, its activity was even more pronounced against sheep red blood cell-induced edema in mouse paws, with a clear reduction in the production of IL-1beta, IL-4, and tumor necrosis factor alpha in the inflamed paw. "
5.	Experimental Arthritis 02/01/2007 - "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages."

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Cytokines
3.	Interleukin-4 (Interleukin 4)
4.	Oxazolone
5.	Dinitrofluorobenzene