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4'- deaza- 1'- aza- 2'- deoxy- 1'- (9- methylene)- immucillin A

structure in first source

Also Known As:

4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A; DADMe-ImmA

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin A: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin A: 2

Experts

1.	Basu, Indranil: 2 articles (01/2008 - 07/2007)
2.	Belbin, Thomas J: 2 articles (01/2008 - 07/2007)
3.	Cordovano, Grace: 2 articles (01/2008 - 07/2007)
4.	Guha, Chandan: 2 articles (01/2008 - 07/2007)
5.	Schramm, Vern L: 2 articles (01/2008 - 07/2007)
6.	Evans, Gary B: 1 article (01/2008)
7.	Furneaux, Richard H: 1 article (01/2008)
8.	Gutierrez, Jemy A: 1 article (01/2008)
9.	Tyler, Peter C: 1 article (01/2008)
10.	Das, Ishita: 1 article (07/2007)

Related Diseases

1.	Neoplasms (Cancer) 07/20/2007 - "FaDu tumors in a mouse xenograft model were treated with MT-DADMe-ImmA, resulting in tumor remission. " 01/01/2008 - "Its transition state structure was used to guide synthesis of MT-DADMe-ImmA, a picomolar inhibitor that shows anticancer effects against solid tumors. " 07/20/2007 - "The selective action of MT-DADMe-ImmA on head and neck squamous cell carcinoma cells suggests potential as an agent for treatment of cancers sensitive to reduced CpG island methylation."
2.	Squamous Cell Carcinoma of Head and Neck 07/20/2007 - "The selective action of MT-DADMe-ImmA on head and neck squamous cell carcinoma cells suggests potential as an agent for treatment of cancers sensitive to reduced CpG island methylation." 07/20/2007 - "Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibited MTAP, increased cellular MTA concentrations, decreased polyamines, and induced apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. "

Related Drugs and Biologics

1.	Polyamines
2.	Pemetrexed (MTA)