Type 6 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.

Also Known As:

Cyclic Nucleotide Phosphodiesterases, Type 6; Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit; PDE6 Phosphodiesterases; PDE6, alpha Subunit; PDE6, beta Subunit; PDE6, delta Subunit; Phosphodiesterase 6; Phosphodiesterase Type 6; Retinal Phosphodiesterase 6; Retinal Phosphodiesterase, alpha Subunit; Retinal Phosphodiesterase, beta Subunit; Retinal Phosphodiesterase, delta Subunit; Rod cGMP Phosphodiesterase, beta Subunit; alpha Subunit, PDE6; beta Subunit, PDE6; cGMP Phosphodiesterase delta Subunit; cGMP-PDE gamma Subunit; delta Subunit, PDE6; gamma Subunit, cGMP Phosphodiesterase; PDE6 alpha Subunit; PDE6 beta Subunit; PDE6 delta Subunit; Phosphodiesterase 6, Retinal; Phosphodiesterases, PDE6; alpha Subunit PDE6; beta Subunit PDE6; cGMP PDE gamma Subunit; delta Subunit PDE6; gamma Subunit, cGMP-PDE

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        3',5'-Cyclic-AMP Phosphodiesterases: 185
        Type 6 Cyclic Nucleotide Phosphodiesterases: 35
        3',5'-Cyclic-GMP Phosphodiesterases
        Type 6 Cyclic Nucleotide Phosphodiesterases: 35
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - 3',5'-Cyclic-AMP Phosphodiesterases: 185
      - Type 6 Cyclic Nucleotide Phosphodiesterases: 35
    - 3',5'-Cyclic-GMP Phosphodiesterases
      - Type 6 Cyclic Nucleotide Phosphodiesterases: 35

human PDE6B protein

Bio-Agent Context: Research Results