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dehydroaripiprazole

a metabolite of aripiprazole

Also Known As:

dehydro-aripiprazole; 2(1H)-Quinolinone, 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-

Networked: 15 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - dehydroaripiprazole: 15
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        dehydroaripiprazole: 15

Experts

1.	Kondo, Tsuyoshi: 6 articles (01/2017 - 10/2009)
2.	Mihara, Kazuo: 6 articles (01/2017 - 10/2009)
3.	Nagai, Goyo: 6 articles (01/2017 - 10/2009)
4.	Nakamura, Akifumi: 6 articles (01/2017 - 10/2009)
5.	Suzuki, Takeshi: 6 articles (01/2017 - 10/2009)
6.	Kagawa, Shoko: 5 articles (01/2017 - 02/2011)
7.	Nemoto, Kenji: 5 articles (01/2017 - 02/2011)
8.	Kawamura, Akio: 2 articles (10/2014 - 09/2012)
9.	Nagasaka, Yasuhisa: 2 articles (10/2014 - 09/2012)
10.	Oda, Kazuo: 2 articles (10/2014 - 09/2012)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2022 - "TDM of aripiprazole (ARI) and its active metabolite dehydroaripiprazole (DHA) was performed for patients diagnosed with schizophrenia (ICD-10 F20.00; F20.01; F20.02). " 01/01/2017 - "It has been suggested that a plasma trough concentration of aripiprazole plus its active metabolite, dehydroaripiprazole of 225 ng/mL is a threshold for a good therapeutic response in the treatment of acutely exacerbated patients with schizophrenia. " 01/01/2017 - "Prediction of an Optimal Dose of Aripiprazole in the Treatment of Schizophrenia From Plasma Concentrations of Aripiprazole Plus Its Active Metabolite Dehydroaripiprazole at Week 1." 12/01/2011 - "Aripiprazole and dehydroaripiprazole plasma concentrations and clinical responses in patients with schizophrenia." 08/01/2010 - "Simultaneous determination of aripiprazole and its active metabolite, dehydroaripiprazole, in plasma by capillary electrophoresis combining on-column field-amplified sample injection and application in schizophrenia."
2.	Tic Disorders (Tic Disorder) 01/01/2022 - "Objective: This study aims to develop a combined population pharmacokinetic (PPK) model for aripiprazole (ARI) and its main active metabolite dehydroaripiprazole (DARI) in pediatric patients with tic disorders (TD), to investigate the inter-individual variability caused by physiological and genetic factors in pharmacokinetics of ARI and optimize the dosing regimens for pediatric patients. "
3.	Breast Neoplasms (Breast Cancer) 10/01/2014 - "Impact of genetic deficiencies of P-glycoprotein and breast cancer resistance protein on pharmacokinetics of aripiprazole and dehydroaripiprazole." 09/01/2012 - "The inhibition potencies of aripiprazole and its active metabolite, dehydroaripiprazole, on the activities of human multidrug resistance protein 1 (MDR1/ABCB1; P-glycoprotein), breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4), that are drug efflux transporters expressed both in the intestine and at the blood-brain barrier (BBB), were investigated. " 10/01/2014 - "1. We investigated how deficiencies in P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) affect the pharmacokinetics of atypical antipsychotics aripiprazole and its active metabolite (dehydroaripiprazole) using normal Friend leukemia virus strain B (FVB) mice, BCRP knockout (Bcrp[-/-]) mice, and P-gp and BCRP triple knockout (Mdr1a/1b[-/-]Bcrp[-/-]) mice. "
4.	Leukemia 10/01/2014 - "1. We investigated how deficiencies in P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) affect the pharmacokinetics of atypical antipsychotics aripiprazole and its active metabolite (dehydroaripiprazole) using normal Friend leukemia virus strain B (FVB) mice, BCRP knockout (Bcrp[-/-]) mice, and P-gp and BCRP triple knockout (Mdr1a/1b[-/-]Bcrp[-/-]) mice. "
5.	Mental Disorders (Mental Disorder) 12/01/2020 - "Concentrations of aripiprazole and dehydroaripiprazole in hair segments from deceased individuals with mental disorders."

Related Drugs and Biologics

1.	Aripiprazole (Abilify)
2.	Carbamazepine (Tegretol)
3.	Risperidone (Risperdal Consta)
4.	Clozapine (Clozaril)
5.	Olanzapine (Zyprexa)
6.	Quetiapine Fumarate (Seroquel)
7.	Cytochrome P-450 CYP2D6 (CYP2D6)
8.	Member 1 Subfamily B ATP Binding Cassette Transporter
9.	Antipsychotic Agents (Antipsychotics)
10.	Proteins (Proteins, Gene)