Type 1 Cyclic Nucleotide Phosphodiesterases

A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.

Also Known As:

Cyclic Nucleotide Phosphodiesterases, Type 1; Ca(2+)-CaM-Stimulated PDE; Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase; Ca-CaM-Phosphodiesterase; Calcium-Calmodulin-Dependent Phosphodiesterase; Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase; Calmodulin Phosphodiesterase; Calmodulin-Dependent Phosphodiesterase; Calmodulin-Dependent cGMP Phosphodiesterase; Cyclic Nucleotide Phosphodiesterase PDE1 Family; Cyclic Nucleotide Phosphodiesterases, Type 1A; Cyclic Nucleotide Phosphodiesterases, Type 1B; Cyclic Nucleotide Phosphodiesterases, Type 1C; PDE1 Phosphodiesterases; Phosphodiesterase 1A, Calmodulin-Dependent; Phosphodiesterase 1B, Calmodulin-Dependent; Phosphodiesterase 1C, Calmodulin-Dependent; Ca CaM Phosphodiesterase; Calcium Calmodulin Dependent Phosphodiesterase; Calcium Calmodulin Stimulated Cyclic AMP Phosphodiesterase; Calmodulin Dependent Phosphodiesterase; Calmodulin Dependent cGMP Phosphodiesterase; Calmodulin-Dependent Phosphodiesterase 1A; Calmodulin-Dependent Phosphodiesterase 1B; Calmodulin-Dependent Phosphodiesterase 1C; Phosphodiesterase 1A, Calmodulin Dependent; Phosphodiesterase 1B, Calmodulin Dependent; Phosphodiesterase 1C, Calmodulin Dependent; Phosphodiesterase, Calcium-Calmodulin-Dependent; Phosphodiesterase, Calmodulin-Dependent cGMP; Phosphodiesterases, PDE1; cGMP Phosphodiesterase, Calmodulin-Dependent; Cyclic Nucleotide Phosphodiesterases, Type I

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        3',5'-Cyclic-AMP Phosphodiesterases: 185
        Type 1 Cyclic Nucleotide Phosphodiesterases: 4
        3',5'-Cyclic-GMP Phosphodiesterases
        Type 1 Cyclic Nucleotide Phosphodiesterases: 4
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - 3',5'-Cyclic-AMP Phosphodiesterases: 185
      - Type 1 Cyclic Nucleotide Phosphodiesterases: 4
    - 3',5'-Cyclic-GMP Phosphodiesterases
      - Type 1 Cyclic Nucleotide Phosphodiesterases: 4

human PDE1A protein

Bio-Agent Context: Research Results