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13-hydroxyellipticine

forms DNA adducts; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Frei, E: 1 article (01/2011)
2.	Rupertová, M: 1 article (01/2011)
3.	Stiborová, M: 1 article (01/2011)
4.	Aimová, Dagmar: 1 article (07/2007)
5.	Eckschlager, Tomás: 1 article (07/2007)
6.	Frei, Eva: 1 article (07/2007)
7.	Gomez, Jacobo E: 1 article (07/2007)
8.	Hrabeta, Jan: 1 article (07/2007)
9.	Poljaková, Jitka: 1 article (07/2007)
10.	Stiborová, Marie: 1 article (07/2007)

Related Diseases

1.	Leukemia 07/18/2007 - "Ellipticine induces formation of two DNA adducts in leukemia HL-60 and CCRF-CEM cells, identical with deoxyguanosine adducts generated by ellipticine metabolites 13-hydroxyellipticine and 12-hydroxyellipticine in vitro and in vivo. " 01/01/2011 - "In contrast, two carbenium ions, ellipticine-13-ylium and ellipticine-12-ylium, derived from two activation ellipticine metabolites, 13-hydroxyellipticine and 12-hydroxyellipticine, generate two major deoxyguanosine adducts in DNA found in the human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells and glioblastoma U87MG cells in vitro and in rat breast carcinoma in vivo. "
2.	Neuroblastoma 01/01/2011 - "In contrast, two carbenium ions, ellipticine-13-ylium and ellipticine-12-ylium, derived from two activation ellipticine metabolites, 13-hydroxyellipticine and 12-hydroxyellipticine, generate two major deoxyguanosine adducts in DNA found in the human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells and glioblastoma U87MG cells in vitro and in rat breast carcinoma in vivo. "
3.	Neoplasms (Cancer) 01/01/2011 - "It also suggests ellipticine reactive metabolites 13-hydroxyellipticine and 12-hydroxyellipticine to be good candidates for targeting to tumors absent from the CYP and peroxidase activation enzymes."
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2011 - "In contrast, two carbenium ions, ellipticine-13-ylium and ellipticine-12-ylium, derived from two activation ellipticine metabolites, 13-hydroxyellipticine and 12-hydroxyellipticine, generate two major deoxyguanosine adducts in DNA found in the human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells and glioblastoma U87MG cells in vitro and in rat breast carcinoma in vivo. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2011 - "In contrast, two carbenium ions, ellipticine-13-ylium and ellipticine-12-ylium, derived from two activation ellipticine metabolites, 13-hydroxyellipticine and 12-hydroxyellipticine, generate two major deoxyguanosine adducts in DNA found in the human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells and glioblastoma U87MG cells in vitro and in rat breast carcinoma in vivo. "

Related Drugs and Biologics

1.	Deoxyguanosine
2.	12-hydroxyellipticine
3.	ellipticine
4.	DNA Adducts
5.	Peroxidase (Myeloperoxidase)
6.	Ions
7.	Enzymes
8.	DNA (Deoxyribonucleic Acid)