montanine

03/15/2017 - "In mice with CIA, treatment with montanine reduced severity of arthritis and joint damage assessed by clinical (P<0.001) and histological (P<0.05) scores and ameliorated articular nociception (P<0.05). "
03/15/2017 - "In this context, we evaluated whether montanine has a disease modifying anti-rheumatic activity in two arthritis models and its effect in vitro on lymphocyte proliferation and on invasiveness of fibroblast-like synoviocytes (FLS). "
03/15/2017 - "Our findings suggest that montanine can be further explored as an innovative pharmacological approach for autoimmune diseases such as arthritis."

10/01/2023 - "However, the native montanine exhibited the greatest antiproliferative activity against cancer cells, with a lower mean IC50 value of 1.39 µM, compared to the displayed mean IC50 values of 2.08 µM for 12 and 3.57 µM for 14. "
10/01/2023 - "The possible molecular mechanisms by which montanine exerts its inhibitory effects against cancer cells have not been documented. "
10/01/2023 - "Antiproliferative activity and apoptosis-inducing mechanism of Amaryllidaceae alkaloid montanine on A549 and MOLT-4 human cancer cells."
01/01/2018 - "Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells."
10/01/2023 - "In the present study, montanine, manthine and a series of 15 semisynthetic montanine analogues originating from the parent alkaloid montanine were screened at a single test dose of 10 μM to explore their cytotoxic activities against a panel of eight cancer cell lines and one non-cancer cell line. "

01/06/2023 - "The synergism between montanine and benznidazole emerges as a potential combination for future studies to treat Chagas disease."

11/01/2021 - "Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study."

06/29/2021 - "Pancracine, a Montanine-Type Amaryllidaceae Alkaloid, Inhibits Proliferation of A549 Lung Adenocarcinoma Cells and Induces Apoptotic Cell Death in MOLT-4 Leukemic Cells."
10/01/2023 - "Our findings provide new insights into the mechanisms underlying the cytostatic, cytotoxic and pro-apoptotic activities of montanine alkaloids in lung adenocarcinoma A549 and leukemic MOLT-4 cancer cell types."