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A-841720

structure in first source

Also Known As:

9-dimethylamino-3-(N-hexamethyleneiminyl)-3H-5-thia-1,3,6-triazafluoren-4-one

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - A-841720: 3

Experts

1.	Baker, Scott: 1 article (02/2008)
2.	Brioni, Jorge D: 1 article (02/2008)
3.	Chang, Renjie: 1 article (02/2008)
4.	EI-Kouhen, Odile: 1 article (02/2008)
5.	Gauvin, Donna M: 1 article (02/2008)
6.	Hernandez, Gricelda: 1 article (02/2008)
7.	Hollingsworth, Peter R: 1 article (02/2008)
8.	Honore, Prisca: 1 article (02/2008)
9.	Lehto, Sonya G: 1 article (02/2008)
10.	Moreland, Robert B: 1 article (02/2008)

Related Diseases

1.	Pain (Aches) 07/01/2007 - "Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition." 11/01/2006 - "We characterized the effects of A-841720, a novel, potent and non-competitive mGluR1 antagonist in models of pain and of motor and cognitive function. " 07/01/2007 - "In the current study we compared the potency of the selective metabotropic glutamate receptor (mGluR1) antagonist A-841720 (7-Azepan-1-yl-4-dimethylamino-7H-9-thia-1,5,7-triaza-fluoren-8-one) in rodent models of pain with its effects in models of learning and memory, to obtain information regarding the therapeutic window of this compound. " 11/01/2006 - "Intraperitoneal injection of A-841720 potently reduced complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 micromol kg(-1)) and monoiodoacetate-induced joint pain (ED50 = 43 micromol kg(-1)). "
2.	Postoperative Pain 02/12/2008 - "In the present study, effects of potent and selective mGlu1 receptor antagonists A-841720, A-794282, A-794278, and A-850002 were evaluated in a skin incision-induced post-operative pain model in rats. " 02/12/2008 - "In this model, A-841720, A-794282, A-794278, and A-850002 induced significant attenuation of spontaneous post-operative pain behavior, with ED50s of 10, 50, 50, and 65 micromol/kg i.p., respectively. "
3.	Hyperalgesia 11/01/2006 - "A-841720 also decreased mechanical allodynia observed in both the sciatic nerve chronic constriction injury and L5-L6 spinal nerve ligation (SNL) models of neuropathic pain (ED50 = 28 and 27 micromol kg(-1), respectively). " 07/01/2007 - "A-841720 significantly reduced formalin-induced behaviours and complete Freund's adjuvant (CFA)-induced tactile allodynia, starting at doses of 1 and 10 mg/kg, respectively. "
4.	Arthralgia (Joint Pain) 11/01/2006 - "Intraperitoneal injection of A-841720 potently reduced complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 micromol kg(-1)) and monoiodoacetate-induced joint pain (ED50 = 43 micromol kg(-1)). "
5.	Neuralgia (Stump Neuralgia) 11/01/2006 - "A-841720 also decreased mechanical allodynia observed in both the sciatic nerve chronic constriction injury and L5-L6 spinal nerve ligation (SNL) models of neuropathic pain (ED50 = 28 and 27 micromol kg(-1), respectively). "

Related Drugs and Biologics

1.	metabotropic glutamate receptor type 1
2.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
3.	9- dimethylamino- 3- (4- methylphenyl)- 3H- 5- thia- 1,3,6- triazafluoren- 4- one
4.	9- dimethylamino- 3- cycloheptyl- 3H- 5- thia- 1,3,6- triazafluoren- 4- one
5.	9- dimethylamino- 3- (4- ethylphenyl)- 3H- 5- thia- 1,3,6- triazafluoren- 4- one
6.	Freund's Adjuvant
7.	Formaldehyde (Formol)

Related Therapies and Procedures

1.	Ligation
2.	Intraperitoneal Injections