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1,2,6,7,8,8a- hexahydro- beta,delta,6- trihydroxy- 2- methyl- 8- (2- methyl- 1- oxobutoxy)- 1- naphthaleneheptanoic acid 4-(nitrooxy)butyl ester

NCX-6550 is the ((1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta-(R*),8aalpha))-isomer; a nitric oxide donor

Also Known As:

NCX 6550; NCX-6550; NCX6550

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Nitrates: 6625
        1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid 4-(nitrooxy)butyl ester: 2
- Nitrogen Compounds: 67
  - Nitric Acid: 155
    - Nitrates: 6625
      - 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid 4-(nitrooxy)butyl ester: 2
Organic Chemicals: 133
- Nitrates: 6625
  - 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid 4-(nitrooxy)butyl ester: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Pravastatin: 1866
        1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid 4-(nitrooxy)butyl ester: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Pravastatin: 1866
      - 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid 4-(nitrooxy)butyl ester: 2

Experts

1.	D'Amico, Michele: 1 article (08/2010)
2.	Di Filippo, Clara: 1 article (08/2010)
3.	Monopoli, Angela: 1 article (08/2010)
4.	Ongini, Ennio: 1 article (08/2010)
5.	Perretti, Mauro: 1 article (08/2010)
6.	Caracchini, R: 1 article (11/2005)
7.	Colucci, M: 1 article (11/2005)
8.	Giannini, S: 1 article (11/2005)
9.	Gresele, P: 1 article (11/2005)
10.	Guglielmini, G: 1 article (11/2005)

Related Diseases

1.	Myocardial Infarction 08/01/2010 - "These results indicate Ncx-6550 as a novel therapeutic agent with a potential for the treatment of myocardial infarct."
2.	Pulmonary Embolism 11/01/2005 - "In a mouse model of platelet pulmonary thromboembolism, induced by the i.v. injection of collagen plus epinephrine, pretreatment with NCX-6550 (24-48 mg kg(-1)) significantly reduced platelet consumption, lung vessel occlusion and mortality. "
3.	Infarction (Infarctions) 08/01/2010 - "In vehicle-treated mice, infarct size (expressed as fraction of area at risk; IS/AR) was 41.2 +/- 1%, and it was reduced to 22.2 +/- 0.9% and 32.6 +/- 0.9% following 22.4 and 6.72 micromol/kg Ncx-6550 (p < 0.05). "

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Collagen