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N- (3- ((2- (4- amino- 1,2,5- oxadiazol- 3- yl)- 1- ethyl- 1H- imidazo(4,5- c)pyridin- 6- yl)oxy)phenyl)- 4- ((2- (4- morpholinyl)ethyl)oxy)benzamide

an NSAID that has vasodilator activity and inhibits Rho kinases; structure in first source

Also Known As:

GSK 269962A; GSK-269962A; GSK269962A

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - N-(3-((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo(4,5-c)pyridin-6-yl)oxy)phenyl)-4-((2-(4-morpholinyl)ethyl)oxy)benzamide: 2
    - Oxazoles: 89
      - Oxadiazoles: 146
        N-(3-((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo(4,5-c)pyridin-6-yl)oxy)phenyl)-4-((2-(4-morpholinyl)ethyl)oxy)benzamide: 2

Experts

1.	Bamford, Mark: 1 article (01/2007)
2.	Behm, David J: 1 article (01/2007)
3.	Bentley, Ross: 1 article (01/2007)
4.	Chen, Zunxuan: 1 article (01/2007)
5.	Doe, Chris: 1 article (01/2007)
6.	Dul, Edward: 1 article (01/2007)
7.	Grygielko, Eugene: 1 article (01/2007)
8.	Hu, Erding: 1 article (01/2007)
9.	Jolivette, Larry: 1 article (01/2007)
10.	Jung, David: 1 article (01/2007)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2022 - "Preclinical evaluation of the ROCK1 inhibitor, GSK269962A, in acute myeloid leukemia."
2.	Neoplasms (Cancer) 01/01/2022 - "Compared with solid tumors, GSK269962A selectively inhibited cell growth and clonogenicity of AML cells. "
3.	Leukemia 01/01/2022 - "Strikingly, GSK269962A could eliminate leukemia cells from bone marrow, liver, and spleen in an animal model of AML and significantly prolong mouse survival. "
4.	Chronic Disease (Chronic Diseases) 01/01/2007 - "SB-772077-B and GSK269962A represent a novel class of ROCK inhibitors that have profound effects in the vasculature and may enable us to further evaluate the potential beneficial effects of ROCK inhibition in animal models of cardiovascular as well as other chronic diseases."

Related Drugs and Biologics

1.	4- (7- ((3- amino- 1- pyrrolidinyl)carbonyl)- 1- ethyl- 1H- imidazo(4,5- c)pyridin- 2- yl)- 1,2,5- oxadiazol- 3- amine