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SecinH3

a small molecule antagonist of cytohesins; structure in first source

Networked: 14 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - SecinH3: 14

Experts

1.	Fukaya, Masahiro: 2 articles (05/2022 - 11/2021)
2.	Ito, Akiko: 2 articles (05/2022 - 11/2021)
3.	Okamoto, Hirotsugu: 2 articles (05/2022 - 11/2021)
4.	Sakagami, Hiroyuki: 2 articles (05/2022 - 11/2021)
5.	Li, Dean Y: 2 articles (02/2016 - 12/2012)
6.	Cai, Cong: 1 article (01/2022)
7.	Cheng, Ze: 1 article (01/2022)
8.	Han, Li: 1 article (01/2022)
9.	Jin, Meilin: 1 article (01/2022)
10.	Jin, Zehua: 1 article (01/2022)

Related Diseases

1.	Osteoporosis 11/01/2022 - "In vivo treatment with SecinH3 ameliorates ovariectomy-induced osteoporosis. "
2.	Heart Failure 10/17/2016 - "In addition, SecinH3 significantly inhibited increase in vascular permeability, and the progression of heart failure was significantly relieved. "
3.	Lung Injury 12/01/2015 - "To study the mechanism of SecinH3 in the process of lung injury induced by the sepsis, the rats with the successful modeling of sepsis were randomly divided into two groups. " 12/01/2015 - "To study effect of SecinH3 on lung injury induced by the sepsis of rats. " 12/01/2015 - "SecinH3 can significantly inhibit the cytohesins and then relieve the lung injury induced by the sepsis of rats." 12/01/2015 - "After being treated by SecinH3, Pa/O2 was increased with the sepsis, while Pa/CO2 was decreased with the action of SecinH3, which indicated that SecinH3 had the certain 'repairing' ability for the lung injury. " 12/01/2015 - "Effect of SecinH3 on lung injury induced by sepsis of rats."
4.	Sepsis (Septicemia) 12/01/2015 - "To study the mechanism of SecinH3 in the process of lung injury induced by the sepsis, the rats with the successful modeling of sepsis were randomly divided into two groups. " 12/01/2015 - "To study effect of SecinH3 on lung injury induced by the sepsis of rats. " 12/01/2015 - "SecinH3 can significantly inhibit the cytohesins and then relieve the lung injury induced by the sepsis of rats." 12/01/2015 - "After being treated by SecinH3, Pa/O2 was increased with the sepsis, while Pa/CO2 was decreased with the action of SecinH3, which indicated that SecinH3 had the certain 'repairing' ability for the lung injury. " 12/01/2015 - "Effect of SecinH3 on lung injury induced by sepsis of rats."
5.	Neoplasms (Cancer) 02/01/2016 - "SecinH3 mediated its effect by reducing tumor angiogenesis rather than directly affecting cancer cell proliferation. " 01/01/2018 - "ARF6 inhibition alone was not toxic; however, the ARF6 inhibitors SecinH3 and NAV2729 dramatically enhanced the killing of cancer cells by SH-BC-893 without increasing toxicity to peripheral blood mononuclear cells, suggesting that ARF6 inactivation contributes to the anti-neoplastic actions of sphingolipids. "

Related Drugs and Biologics

1.	Apoptosis Regulatory Proteins
2.	Angiopoietin-2
3.	Angiopoietin-1
4.	Small Interfering RNA (siRNA)
5.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
6.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
7.	NF-kappa B (NF-kB)
8.	Sphingolipids
9.	Proteins (Proteins, Gene)
10.	Atrial Natriuretic Factor (ANF)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)