4'-demethylnobiletin

structure in first source

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 06/21/2019 - "Not only does nobiletin itself exhibit anti-cancer properties, but its derivatives are also promising chemopreventive agents; examples of derivatives with anti-cancer activity include 3'-demethylnobiletin (3'-DMN), 4'-demethylnobiletin (4'-DMN), 3',4'-didemethylnobiletin (3',4'-DMN) and 5-demethylnobiletin (5-DMN). "
2.	Memory Disorders (Memory Loss) 08/18/2009 - "Therefore, these results suggest that 4'-demethylnobiletin, a bioactive metabolite of nobiletin, may serve as a potential therapeutic agent, at least, for memory disorders associated with a dysregulated NMDA receptor ERK signaling, like nobiletin."
3.	Inflammation (Inflammations) 12/30/2015 - "We reported previously that 4'-demethylnobiletin (4DN), a major metabolite of NOB, significantly inhibited lipopolysaccharide (LPS)-stimulated inflammation in RAW 264.7 macrophages. " 12/30/2015 - "Inhibitory Effects of 4'-Demethylnobiletin, a Metabolite of Nobiletin, on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Induced Inflammation in Mouse Ears."
4.	Colonic Neoplasms (Colon Cancer) 01/24/2018 - "A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis."
5.	Bone Resorption 03/14/2023 - "Effects of 4'-Demethylnobiletin and 4'-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption."

1.	nobiletin
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Lipopolysaccharides
4.	Estrogens (Estrogen)
5.	Atorvastatin (Lipitor)
6.	3',4'-didemethylnobiletin
7.	3'-demethylnobiletin
8.	5-demethylnobiletin