IDN5174

a synthetic camptothecin with the open lactone ring; structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

1.	Battaglia, Arturo: 1 article (11/2006)
2.	Bello, Ezia: 1 article (11/2006)
3.	Beretta, Giovanni L: 1 article (11/2006)
4.	Bombardelli, Ezio: 1 article (11/2006)
5.	De Cesare, Michelandrea: 1 article (11/2006)
6.	Fontana, Gabriele: 1 article (11/2006)
7.	Frapolli, Roberta: 1 article (11/2006)
8.	Manzotti, Carla: 1 article (11/2006)
9.	Perego, Paola: 1 article (11/2006)
10.	Petrangolini, Giovanna: 1 article (11/2006)

1.	Neoplasms (Cancer) 11/15/2006 - "The pharmacokinetics in mice showed a favorable disposition in tumor tissue with low amount of camptothecin detectable in plasma and tumor (around 5-10%), thus supporting the efficacy of intact IDN5174. " 11/15/2006 - "IDN5174 exhibited an antitumor activity comparable with that of topotecan and irinotecan against NCI-H460 tumor xenograft. "