SB-699551-A
5-ht5A receptor-selective antagonist that enhances 5-HT neuronal function; structure in first source
Also Known As:
3-cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-(((2-phenylethyl)amino)methyl)-4-biphenylyl)methyl)propanamide dihydrochloride
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1. | Shock
08/01/2012
- " Two 5-HT5A antagonist ligands, SB-699551-A (N-[2-(dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride) (3-60 mg/kg, intraperitoneally) and A-843277 (N-(2,6-dimethoxybenzyl)-N'[4-(4-fluorophenyl)thiazol-2-yl]guanidine) (3-30 mg/kg, intraperitoneally), were examined in the open-field test, in a foot-shock-induced ultrasonic vocalization test, in the forced swim test (FST) and in the amphetamine-induced and phencyclidine-induced hyperlocomotion tests to examine their effect on general behavioural patterns, and their anxiolytic-like, antidepressant-like and antipsychotic-like properties, respectively. "
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