HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

amorpha-4,11-diene

a precursor to the antimalarial drug artemisinin

Also Known As:

amorphadiene

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Polycyclic Sesquiterpenes: 9
        amorpha-4,11-diene: 3
Polycyclic Compounds: 6
- Polycyclic Sesquiterpenes: 9
  - amorpha-4,11-diene: 3

Experts

1.	Chen, Xixian: 1 article (01/2019)
2.	Shukal, Sudha: 1 article (01/2019)
3.	Zhang, Congqiang: 1 article (01/2019)
4.	Allemann, Rudolf K: 1 article (01/2018)
5.	Demiray, Melodi: 1 article (01/2018)
6.	Tang, Xiaoping: 1 article (01/2018)
7.	Wirth, Thomas: 1 article (01/2018)
8.	Basmanj, Maryam Taghavi: 1 article (07/2017)
9.	Eslami, Habib: 1 article (07/2017)
10.	Mohtashami, Seyed Kaveh: 1 article (07/2017)

Related Diseases

1.

01/01/2019 - "As a proof-of-concept example, we applied the knowledge to amorphadiene, anti-malaria drug artemisinin precursor, achieved 30 g/L. "
07/01/2017 - "The enzyme amorphadiene synthase (ADS) conducts the first committed step in the biosynthetic conversion of the substrate farnesyl pyrophosphate (FPP) to artemisinin, which is a highly effective natural product against multidrug-resistant strains of malaria. "
01/01/2018 - "Amorphadiene synthase, a key enzyme in the biosynthetic pathway of artemisinin, is able to convert an oxygenated farnesyl diphosphate analogue directly to dihydroartemisinic aldehyde, which can be converted to artemisinin in only four chemical steps, resulting in an efficient synthetic route to the anti-malaria drug."

Related Drugs and Biologics

1.	artemisinin (artemisinine)
2.	Enzymes
3.	farnesyl pyrophosphate (farnesyl diphosphate)
4.	Aldehydes