bastadin 6

a macrocyclic tetramer of a spongean brominated tyrosine derivative that inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Aoki, Shunji: 1 article (03/2006)
2.	Cho, Seok-hwan: 1 article (03/2006)
3.	Gao, Jian-Qing: 1 article (03/2006)
4.	Kobayashi, Motomasa: 1 article (03/2006)
5.	Kuwano, Michihiko: 1 article (03/2006)
6.	Kuwano, Takashi: 1 article (03/2006)
7.	Mayumi, Tadanori: 1 article (03/2006)
8.	Nakagawa, Shinsaku: 1 article (03/2006)
9.	Nakao, Shintaro: 1 article (03/2006)
10.	Ono, Mayumi: 1 article (03/2006)

Related Diseases

1.

Neoplasms (Cancer) 03/01/2006 - "Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells." 03/01/2006 - "Bastadin 6 was found to inhibit vascular endothelial growth factor (VEGF)- or basic fibroblast growth factor (bFGF)-dependent proliferation (IC50=0.052 micromol/l) of human umbilical vein endothelial cells (HUVECs) 20- to 100-fold selectively in comparison with normal fibroblast (3Y1) or several tumor cells (KB3-1, K562 and Neuro2A). "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3.	Tyrosine (L-Tyrosine)