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glycycoumarin

from the root of Glycyrrhizae Radix, acts as a potent antispasmodic through inhibition of phosphodiesterase 3; structure in first source

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        glycycoumarin: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        glycycoumarin: 6

Experts

1.	Fan, Lihong: 4 articles (06/2020 - 10/2016)
2.	Hu, Hongbo: 4 articles (06/2020 - 10/2016)
3.	Yin, Shutao: 4 articles (06/2020 - 10/2016)
4.	Zhang, Enxiang: 3 articles (06/2020 - 10/2016)
5.	Zhao, Chong: 2 articles (06/2020 - 02/2020)
6.	Yan, Mingzhu: 1 article (06/2020)
7.	Zhao, Shuang: 1 article (06/2020)
8.	Lu, Shangyun: 1 article (02/2020)
9.	Lu, Xiaotong: 1 article (03/2018)
10.	Ye, Linhu: 1 article (03/2018)

Related Diseases

1.	Liver Diseases (Liver Disease) 06/01/2020 - "Protective effects of glycycoumarin on liver diseases." 03/15/2018 - "Glycycoumarin (GCM) is a representative of bioactive coumarin compounds isolated from licorice, an edible and medicinal plant widely used for treating various diseases including liver diseases. "
2.	Neoplasms (Cancer) 01/01/2023 - "Studies have shown that glycycoumarin has many biological activities, such as anti-tumor, liver protection, antispasmodic, antibacterial, and antivirus. " 10/04/2016 - "Glycycoumarin (GCM) is a major bioactive coumarin compound isolated from licorice and the anti-cancer activity of GCM has not been scientifically addressed. " 02/01/2020 - "In this study, we evaluated the anti-cancer effect of combining glycyrol (GC), a representative of coumarin compounds in licorice, or its analogues Glycycoumarin/Demethylsuberosin/Coumestrol (GCM/De/Coum) with butyrate in HT29 and HCT116 cells, and explored the relationship between the combined anti-cancer effect and structural features of coumarin compounds. "
3.	Liver Neoplasms (Liver Cancer) 10/04/2016 - "Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase." 03/15/2018 - "Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis."
4.	Carcinoma (Carcinomatosis) 01/01/2007 - "It showed that umbelliferone, scoparone, demethylfuropinarine, isopimpinellin, forbesoside, columbianadin, decursin and glycycoumarin inhibited the growth of human bladder carcinoma cell line E-J in vitro and their activities showed a concentration-effect relationship. "

Related Drugs and Biologics

1.	coumarin
2.	Parasympatholytics (Antispasmodics)
3.	Coumestrol
4.	Butyrates (Butyrate)
5.	glycyrol
6.	Protein Kinases (Protein Kinase)
7.	Survivin
8.	ABT-737
9.	decursin
10.	columbianadin