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14-hydroxy-10-deacetylbaccatin III

structure in first source

Also Known As:

14beta-hydroxy-10-deacetylbaccatin III

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        14-hydroxy-10-deacetylbaccatin III: 2
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        14-hydroxy-10-deacetylbaccatin III: 2

Experts

1.	Eckstein, Jens W: 1 article (06/2004)

Related Diseases

1.

Neoplasms (Cancer)

06/01/2004 - "Bayer Corp, under license from Indena SpA, is developing BAY-59-8862, a taxane synthesized from 14beta-hydroxy-10-deacetylbaccatin III, for the potential treatment of cancer."
09/04/1997 - "Paclitaxel, docetaxel and a series of new analogs synthesized from 14beta-hydroxy-10-deacetylbaccatin III (14-OH-DAB), a natural diterpene closely related to the core synthon of the 2 above prototypes, were tested in vitro for their growth-inhibitory activity on different human cancer cell lines, including some expressing the classic multidrug-resistant (MDR) phenotype (MCF-7 ADRr and CEM VBLr). "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Diterpenes
3.	Docetaxel (Taxotere)
4.	IDN 5109 (BAY 59-8862)
5.	taxane