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BIM 46174

a Galpha/Gbetagamma complex inhibitor; structure in first source

Also Known As:

BIM-46174; BIM46174

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alley, Mike: 1 article (09/2006)
2.	Attoub, Samir: 1 article (09/2006)
3.	Bracke, Mark: 1 article (09/2006)
4.	Brezak, Marie C: 1 article (09/2006)
5.	Bruyneel, Erik: 1 article (09/2006)
6.	Chaumeron, Sophie: 1 article (09/2006)
7.	Coulomb, Hélène: 1 article (09/2006)
8.	Demarquay, Danièle: 1 article (09/2006)
9.	Ferrandis, Eric: 1 article (09/2006)
10.	Forgez, Patricia: 1 article (09/2006)

Related Diseases

1.

Neoplasms (Cancer)

09/15/2006 - "BIM-46174 inhibits the growth of a large panel of human cancer cell lines, including anticancer drug-resistant cells. "
09/15/2006 - "Exposure of cancer cells to BIM-46174 leads to caspase-3-dependent apoptosis and poly(ADP-ribose) polymerase cleavage. "
09/15/2006 - "The growth rate of human tumor xenografts in athymic mice is significantly reduced after administration of BIM-46174 combined with either cisplatin, farnesyltransferase inhibitor, or topoisomerase inhibitors. "
09/15/2006 - "BIM-46174 prevents the heterotrimeric G-protein signaling linked to several GPCRs mediating (a) cyclic AMP generation (Galphas), (b) calcium release (Galphaq), and (c) cancer cell invasion by Wnt-2 frizzled receptors and high-affinity neurotensin receptors (Galphao/i and Galphaq). "

Related Drugs and Biologics

1.	Topoisomerase Inhibitors
2.	Farnesyltranstransferase (Farnesyltransferase)
3.	Frizzled Receptors
4.	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)
5.	Neurotensin Receptors (Neurotensin Receptor)
6.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
7.	Cisplatin (Platino)
8.	Calcium
9.	Cyclic AMP (AMP, Cyclic)