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7-bromoindirubin-3'-oxime

has mild protein kinase inhibitory activity; induces caspase-independent cell death; structure in first source

Also Known As:

7BIO cpd

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 7-bromoindirubin-3'-oxime: 4
Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Oximes: 1292
      - 7-bromoindirubin-3'-oxime: 4

Experts

1.	Houke, Haley R: 1 article (10/2019)
2.	Rice, Charles D: 1 article (10/2019)
3.	Scobie, Micaela R: 1 article (10/2019)
4.	Becher-Boveleth, Nina: 1 article (01/2015)
5.	Broecker-Preuss, Martina: 1 article (01/2015)
6.	Gall, Susanne: 1 article (01/2015)
7.	Mann, Klaus: 1 article (01/2015)
8.	Rehmann, Katrin: 1 article (01/2015)
9.	Schenke, Susann: 1 article (01/2015)
10.	Constantinou, Andreas I: 1 article (08/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/17/2012 - "The objective of the present study was to evaluate and compare the anticancer properties of the two novel bromo-substituted derivatives 6-bromoindirubin-3'-oxime (6BIO) and 7-bromoindirubin-3'-oxime (7BIO) in five different breast cancer cell lines. "
2.	Thyroid Neoplasms (Thyroid Cancer) 01/01/2015 - "Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3'-oxime (7BIO)."
3.	Necrosis 08/01/2009 - "We identify 7-bromoindirubin-3'-oxime, an indirubin oxime derivative that induces necrosis, as a potent inducer of caspase-1 activation and release of mature IL-1beta and IL-18. "
4.	Inflammation (Inflammations) 10/01/2019 - "Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) and 7-bromoindirubin-3'-oxime (7BIO)."
5.	Glioma (Gliomas) 10/01/2019 - "Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by indirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) and 7-bromoindirubin-3'-oxime (7BIO)."

Related Drugs and Biologics

1.	6-bromoindirubin-3'-oxime
2.	indirubin
3.	Interleukin-18 (Interleukin 18)
4.	Oximes
5.	Indirubin E804