|1.||Kellar, Kenneth J: 5 articles (05/2014 - 09/2008)|
|2.||Xiao, Yingxian: 5 articles (05/2014 - 09/2008)|
|3.||Rezvani, Amir H: 3 articles (10/2013 - 06/2011)|
|4.||Levin, Edward D: 3 articles (10/2013 - 06/2011)|
|5.||Blendy, Julie A: 2 articles (05/2014 - 08/2010)|
|6.||Turner, Jill R: 2 articles (05/2014 - 08/2010)|
|7.||Gordon, Christopher J: 2 articles (10/2013 - 05/2012)|
|8.||Sexton, Hannah G: 2 articles (10/2013 - 05/2012)|
|9.||Brown, Milton L: 2 articles (10/2013 - 06/2011)|
|10.||Forcelli, Patrick A: 1 article (05/2014)|
09/01/2012 - "We investigated the antinociceptive effects of two new α4β2* nicotinic partial agonists, varenicline and sazetidine-A, in acute thermal and tonic pain mouse models. "
09/01/2012 - "The antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain models."
09/01/2008 - "The authors investigated the analgesic effects of Sazetidine-A using the formalin model of chronic inflammatory pain. "
09/01/2008 - "Higher doses of Sazetidine-A (0.5, 1, or 2 mg/kg) induced analgesia, with pain scores significantly lower than those seen after saline, lower doses of Sazetidine-A, and epibatidine (P < 0.001). "
09/01/2012 - "In contrast to acute pain tests, varenicline and sazetidine-A dose-dependently induced an analgesic effect in the mouse formalin test after systemic administration. "
10/15/2013 - "Confirming our earlier results, sazetidine-A elicited a pronounced and long-lasting hypothermia in WT mice. "
05/05/2012 - "Acute sazetidine-A caused a pronounced and long-lasting hypothermia in mice; Tc decreased to about 28°C at 100 min and recovered within 230 min. The hypothermic effect of sazetidine in rats was much less in magnitude (about 3°C) and shorter in duration compared with that in mice. "
10/15/2013 - "Three other novel nicotinic receptor desensitizing agents derived from sazetidine-A, triazetidine-O, VMY-2-95 and YL-1-127 also produced hypothermia in WT and α7(-/-) mice. "
10/15/2013 - "Similar to WT mice, α7(-/-) mice showed the full extent of the sazetidine-A effect, suggesting that the hypothermia produced by sazetidine-A did not depend on actions on α7 nicotinic receptor subtype. "
10/15/2013 - "This effect appears to be related to nicotinic receptor desensitization because sazetidine-A, an α4β2 nicotinic receptor desensitizing agent, produces marked hypothermia and potentiates nicotine-induced hypothermia in mice. "
|3.||Mood Disorders (Mood Disorder)
09/01/2008 - "Epibatidine and Sazetidine-A affected animals' locomotor activity for the initial 20 min. While analgesic doses of epibatidine caused seizures, no seizure activity or other neurologic complications were seen in animals that received as much as four times the minimum analgesic dose of Sazetidine-A. "
09/01/2008 - "Effects of Sazetidine-A and epibatidine on locomotor were tested in an open field, and seizure activity was measured using the Racine scale. "
|1.||Nicotinic Receptors (Nicotinic Acetylcholine Receptor)