|1.||Neamati, Nouri: 14 articles (11/2012 - 05/2004)|
|2.||Pommier, Yves: 7 articles (06/2014 - 09/2008)|
|3.||Marchand, Christophe: 5 articles (06/2014 - 09/2008)|
|4.||Zhao, Xue Zhi: 5 articles (06/2014 - 01/2009)|
|5.||Métifiot, Mathieu: 5 articles (06/2014 - 10/2011)|
|6.||Debyser, Zeger: 4 articles (11/2014 - 03/2004)|
|7.||Hughes, Stephen H: 4 articles (06/2014 - 10/2011)|
|8.||Smith, Steven J: 4 articles (06/2014 - 10/2011)|
|9.||Burke, Terrence R: 4 articles (06/2014 - 01/2009)|
|10.||Sanchez, Tino: 4 articles (04/2009 - 05/2004)|
11/15/2005 - "Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3'-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-beta-gal-CD4+ cells."
07/01/2014 - "Dolutegravir (Tivicay(®)) is a new-generation HIV-1 integrase strand transfer inhibitor recently approved in the EU and Japan for the treatment of HIV-1 infection in adolescents and adults in combination with other antiretroviral drugs. "
01/01/2014 - "In last few years quite, a few but potent inhibitors inhibiting HIV-1 integrase have been recognized and hence have gained a state-of-the-art for treating the infection caused by HIV-1. "
10/16/2012 - "HIV-1 integrase strand transfer inhibitors are an important class of compounds targeted for the treatment of HIV-1 infection. "
01/01/2012 - "To identify novel factors involved in HIV-1 replication, HIV-1 integrase and matrix protein complexes were captured at 4 hours post infection for proteomic analysis using an affinity purification system. "
|2.||Acquired Immunodeficiency Syndrome (AIDS)
06/01/2010 - "Our study will be of help to identify the pharmacophores of inhibitors binding to HIV-1 integrase and design new pharmaceuticals for the treatment of AIDS."
12/01/2014 - "X-ray crystallography furthermore elucidated the mechanism of action of HIV-1 integrase strand transfer inhibitors, which are currently used to treat AIDS patients, and provided valuable insights into the mechanisms of viral drug resistance. "
06/26/2014 - "There are currently three HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) approved by the FDA for the treatment of AIDS. "
06/01/2013 - "HIV-1 integrase is an important therapeutic target in the fight against HIV/AIDS. "
07/23/2012 - "HIV-1 integrase (HIV-1 IN) is a recently validated biological target for AIDS therapy. "
|3.||HIV Infections (HIV Infection)
01/01/2010 - "The paper presents the data of an investigation of the polymorphism of the pol gene encoding HIV-1 integrase in a HIV subtype G infected population formed during the 1989 HIV-infection outbreak. "
01/01/2010 - "[Analysis of HIV-1 integrase gene polymorphism in an HIV-infected population from the nosocomial outbreak of HIV infection in the south of Russia in 1989]."
02/24/2003 - "HIV-1 integrase is a novel therapeutic target and is the focus of efforts to identify effective inhibitors that will prevent/or cure HIV infections. "
05/06/2004 - "Discovery of diketoacid-containing compounds as HIV-1 integrase (IN) inhibitors played a major role in validating this enzyme as an important target for the development of therapeutics against HIV infection. "
03/01/2011 - "Since there is no human homolog of this enzyme, HIV-1 integrase (IN) represents a rational and important target for treating HIV infection and preventing AIDS. "
12/15/2008 - "Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines."
11/26/2012 - "Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties."
10/15/2011 - "Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells."
10/01/2002 - "Lamellarin alpha 13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. "
11/12/1999 - "Glycosylase/ap lyase activity explains MAP30's apparent inhibition of the HIV-1 integrase, MAP30's ability to irreversibly relax supercoiled DNA, and may be an alternative cytotoxic pathway that contributes to MAP30's anti-HIV/anti-tumor activities. "
03/15/2010 - "Intensification of antiretroviral therapy with a potent HIV-1 integrase inhibitor did not decrease persistent viremia in subjects receiving suppressive regimens, indicating that rapidly cycling cells infected with HIV-1 were not present. "
10/01/2011 - "Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in patients. "
|2.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|5.||DNA (Deoxyribonucleic Acid)
|7.||Complementary DNA (cDNA)
|10.||Antiviral Agents (Antivirals)
|3.||Highly Active Antiretroviral Therapy (HAART)