Human immunodeficiency virus 1 p31 integrase protein

Also Known As:

p31 integrase protein, Human immunodeficiency virus 1; HIV-1 integrase; p31 pol gene Product, HIV I; p31 pol gene product, Human immunodeficiency virus 1; p31 pol gene product, human immunodeficiency virus type 1

Networked: 118 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Nucleotidyltransferases: 29
        Transposases: 224
        HIV Integrase: 62
        Human immunodeficiency virus 1 p31 integrase protein: 118
  - Recombinases: 454
    - Integrases: 601
      - Transposases: 224
        HIV Integrase: 62
        Human immunodeficiency virus 1 p31 integrase protein: 118
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250

Experts

1.	Neamati, Nouri: 15 articles (01/2017 - 05/2004)
2.	Pommier, Yves: 7 articles (07/2018 - 10/2011)
3.	Zhao, Xue Zhi: 7 articles (07/2018 - 06/2009)
4.	Debyser, Zeger: 6 articles (01/2021 - 03/2004)
5.	Burke, Terrence R: 6 articles (07/2018 - 06/2009)
6.	Métifiot, Mathieu: 6 articles (07/2018 - 10/2011)
7.	Marchand, Christophe: 5 articles (07/2018 - 11/2011)
8.	Hughes, Stephen H: 5 articles (01/2018 - 10/2011)
9.	Smith, Steven J: 5 articles (01/2018 - 10/2011)
10.	Meanwell, Nicholas A: 4 articles (12/2020 - 08/2011)

Related Diseases

1.	Infections 11/15/2005 - "Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3'-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-beta-gal-CD4+ cells." 01/01/2021 - "Here we present results obtained using a novel thermodynamic free energy cycle, for the rational design of allosteric inhibitors of HIV-1 integrase (ALLINI) that act specifically in the early stage of the infection cycle. " 12/01/2020 - "Active site inhibitors of HIV-1 integrase are clinically validated for the treatment of HIV-1 infection. " 01/01/2018 - "INSTIs block the strand transfer reaction catalyzed by HIV-1 integrase (IN) and have been shown to potently inhibit infection by wild-type HIV-1. " 01/01/2017 - "Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 06/01/2010 - "Our study will be of help to identify the pharmacophores of inhibitors binding to HIV-1 integrase and design new pharmaceuticals for the treatment of AIDS." 12/01/2014 - "X-ray crystallography furthermore elucidated the mechanism of action of HIV-1 integrase strand transfer inhibitors, which are currently used to treat AIDS patients, and provided valuable insights into the mechanisms of viral drug resistance. " 06/26/2014 - "There are currently three HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) approved by the FDA for the treatment of AIDS. " 01/01/2014 - "X-ray crystallography furthermore elucidated the mechanism of action of HIV-1 integrase strand transfer inhibitors, which are currently used to treat AIDS patients, and provided valuable insights into the mechanisms of viral drug resistance." 10/01/2013 - "Inhibition of the 3' processing step of HIV-1 integrase by small molecule inhibitors is one of the most promising strategies for the treatment of AIDS. "
3.	Virus Diseases (Viral Diseases) 02/01/2007 - "We show that p21 blocked viral infection by complexing with HIV-1 integrase and aborting chromosomal integration. " 11/15/2020 - "Previous studies have identified a series of imidazo[1,2-a]pyridine (IZP) derivatives as potent allosteric inhibitors of HIV-1 integrase (ALLINIs) and virus infection in cell culture. " 06/16/2011 - "Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. " 08/01/2008 - "HIV-1 integrase (IN) is an essential enzyme for viral infection. " 07/01/2004 - "HIV-1 integrase (IN) is an essential enzyme for effective viral replication and is an attractive target for selective blockade of viral infection. "
4.	HIV Infections (HIV Infection) 01/05/2017 - "Currently, three HIV-1 integrase (IN) active site-directed inhibitors are in clinical use for the treatment of HIV infection. " 10/01/2016 - "HIV-1 integrase (IN) inhibitors are one of the most recent innovations in the treatment of HIV infection. " 01/01/2010 - "The paper presents the data of an investigation of the polymorphism of the pol gene encoding HIV-1 integrase in a HIV subtype G infected population formed during the 1989 HIV-infection outbreak. " 01/01/2010 - "[Analysis of HIV-1 integrase gene polymorphism in an HIV-infected population from the nosocomial outbreak of HIV infection in the south of Russia in 1989]." 02/24/2003 - "HIV-1 integrase is a novel therapeutic target and is the focus of efforts to identify effective inhibitors that will prevent/or cure HIV infections. "
5.	Neoplasms (Cancer) 12/15/2008 - "Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines." 11/26/2012 - "Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties." 01/01/2016 - "Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors." 10/15/2011 - "Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells." 10/01/2002 - "Lamellarin alpha 13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. "

Related Drugs and Biologics

1.	Raltegravir Potassium
2.	Reverse Transcriptase Inhibitors
3.	cabotegravir
4.	pyridine
5.	Acids
6.	Rilpivirine (TMC-278)
7.	Enzymes
8.	Antiviral Agents (Antivirals)
9.	lens epithelium-derived growth factor
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Art Therapy