|1.||Kim, Young-Myeong: 2 articles (07/2010 - 07/2004)|
|2.||Lee, Hansoo: 2 articles (07/2010 - 07/2004)|
|3.||Kwon, Young-Guen: 2 articles (07/2010 - 07/2004)|
|4.||Ha, Kwon-Soo: 2 articles (07/2010 - 07/2004)|
|5.||Kim, Dong Eun: 1 article (10/2014)|
|6.||Kim, Ki Ho: 1 article (10/2014)|
|7.||Jang, Ji Hoon: 1 article (10/2014)|
|8.||Park, Jun-Soo: 1 article (10/2014)|
|9.||Jang, Byeong-Churl: 1 article (10/2014)|
|10.||Lee, Kyung Seop: 1 article (10/2014)|
07/01/2010 - "LB42708 suppressed tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors. "
10/01/2014 - "Taken together, our results show that the activity of BAI plus LB42708 modulate multiple components in apoptotic response of human renal Caki cells, and indicate a potential as combinational therapeutic agents for preventing cancer such as renal carcinoma. "
07/01/2010 - "These data indicate that the antitumor effect of LB42708 can be associated with direct inhibition of VEGF-induced tumor angiogenesis by blocking Ras-dependent MAPK and PI3K/Akt signal pathways in tumor-associated endothelial cells."
01/01/2013 - "Other important FTIs such as BMS-214662, LB42908, LB42708, etc are under clinical studies for the treatment of various cancers. "
07/15/2004 - "Together, these findings reveal that the inhibitory effect of LB42708 on p21(ras)-dependent NF-kappaB activation may have potential therapeutic value for arthritis and other inflammatory diseases."
07/15/2004 - "We synthesized a potent and selective farnesyltransferase inhibitor (LB42708) with IC(50) values of 0.8 nM in vitro and 8 nM in cultured cells against p21(ras) farnesylation and examined the effects of this inhibitor in the settings of inflammation and arthritis. "
07/15/2004 - "Furthermore, in vivo administration of LB42708 significantly decreased the incidence and severity of arthritis as well as mRNA expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta in the paws of collagen-induced arthritic mice compared with controls. "
|2.||7- cyano- 2,3,4,5- tetrahydro- 1- (1H- imidazol- 4- ylmethyl)- 3- (phenylmethyl)- 4- (2- thienylsulfonyl)- 1H- 1,4- benzodiazepine (BMS 214662)
|3.||Cyclooxygenase 2 (Cyclooxygenase-2)
|5.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|6.||Nitric Oxide Synthase (NO Synthase)
|7.||NF-kappa B (NF-kB)
|8.||Proto-Oncogene Proteins p21(ras)
|9.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|10.||Messenger RNA (mRNA)
|1.||Heterologous Transplantation (Xenotransplantation)