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2- amino- 5- (4- chlorophenylethynyl)- 4- (4- hydroxycyclohexylamino)pyrimidine

a neurotrophin potentiator; structure in first source

Also Known As:

2-amino-5-(4-chlorophenylethynyl)-4-(4-trans-hydroxycyclohexylamino)pyrimidine; KP 544; KP-544; KP544 cpd

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Falsig, Jeppe: 1 article (04/2007)
2.	Geist, Marie A: 1 article (04/2007)
3.	Leist, Marcel: 1 article (04/2007)
4.	Podhorna, Jana: 1 article (04/2007)
5.	Volbracht, Christiane: 1 article (04/2007)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/16/2007 - "Chronic treatment of rats with KP-544 prevented the hyper-responsiveness to amphetamine of animals treated with methylazoxymethanol acetate, a recently described neurodevelopmental model of schizophrenia."
2.	Inflammation (Inflammations) 04/16/2007 - "KP-544 also protected the cerebellar granule cells from excitotoxicity apoptosis induced by the mitochondrial toxin methyl-phenyl-pyridinium, and modulated inflammation by inhibiting interleukin-6 production in primary astrocytes. "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Methylazoxymethanol Acetate
3.	Amphetamine (Amfetamine)