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LASSBIO596

a phosphodiesterase inhibitor

Also Known As:

2-(4-(1,4-thiomorpholin-4-ylsulfonyl)phenylcarbamoyl)benzoic acid; LassBio-596

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Barreiro, Eliezer Jesus: 4 articles (04/2022 - 02/2015)
2.	Lima, Lidia Moreira: 4 articles (04/2022 - 01/2012)
3.	Barreiro, Eliezer J: 3 articles (11/2019 - 01/2012)
4.	Barreiro, E J: 3 articles (11/2014 - 07/2003)
5.	Lima, L M: 3 articles (11/2014 - 07/2003)
6.	Lima, Lídia Moreira: 2 articles (11/2019 - 01/2016)
7.	Azevedo, Sandra Maria F O: 2 articles (01/2018 - 02/2015)
8.	Carvalho, Giovanna Marcella Cavalcante: 2 articles (01/2018 - 02/2015)
9.	Oliveira, Vinícius Rosa: 2 articles (01/2018 - 02/2015)
10.	Zin, Walter Araujo: 2 articles (01/2018 - 02/2015)

Related Diseases

1.	Asthma (Bronchial Asthma) 02/01/2006 - "In conclusion, LASSBio596 at a dose of 10 mg/kg effectively prevented lung mechanical and morphometrical changes and had the potential to block fibroproliferation in a BALB/c mouse model of asthma." 02/01/2006 - "The aim of the present study was to compare the efficacy of a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that of dexamethasone in a murine model of chronic asthma. " 11/01/2014 - "LASSBio-596, 2-[4-(1,4-tiazinan-4-ylsulfonyl) phenylcarbamoyl] benzoic acid, is an achiral compound containing a subunit carboxylic amide, was capable of preventing induced mechanical and morphological changes in the lungs that commonly caused the onset of asthma. " 02/01/2006 - "In the dexamethasone (N = 8) and LASSBio596 (N = 8) groups, the animals of the asthma group were treated with 1 mg/kg dexamethasone disodium phosphate (0.1 mL, ip) or 10 mg/kg LASSBio596 dissolved in dimethyl sulfoxide (0.2 mL, ip) 24 h before the first intratracheal instillation of OVA, for 8 days. "
2.	Gastritis 11/15/2019 - "The aim of this study was to evaluate the gastroprotective effect of LASSBio-596 in an ethanol-induced acute gastritis model. "
3.	Wounds and Injuries (Trauma) 04/01/2022 - "LASSBio-596 reduced paw edema from the 15th day to the 21st day of treatment (no liver changes and with fewer paw injuries). " 01/01/2018 - "Microcystin-LR (MC-LR) can cause serious injuries upon short- and long-term exposures that can be prevented by LASSBio-596 (LB-596), an anti-inflammatory compound. "
4.	Pneumonia (Pneumonitis) 01/01/2015 - "We hypothesized that LASSBio-596, a molecule with potent anti-inflammatory and immunomodulatory effects, might reduce pulmonary inflammation and remodeling and thus improve lung function in experimental emphysema. " 01/01/2016 - "We hypothesized that co-administration of LASSBio596, a molecule with significant anti-inflammatory properties, and exogenous surfactant could reduce lung inflammation, thus enabling the surfactant to reduce edema and improve lung function, in experimental ARDS. " 01/01/2015 - "In conclusion, LASSBio-596 therapy reduced lung inflammation, airspace enlargement, and small airway wall remodeling, thus improving lung function, in this animal model of elastase-induced emphysema. "
5.	Edema (Dropsy) 04/01/2022 - "LASSBio-596 reduced paw edema from the 15th day to the 21st day of treatment (no liver changes and with fewer paw injuries). " 01/01/2016 - "We hypothesized that co-administration of LASSBio596, a molecule with significant anti-inflammatory properties, and exogenous surfactant could reduce lung inflammation, thus enabling the surfactant to reduce edema and improve lung function, in experimental ARDS. "

Related Drugs and Biologics

1.	Dexamethasone (Maxidex)
2.	Type 4 Cyclic Nucleotide Phosphodiesterases
3.	Ethanol (Ethyl Alcohol)
4.	Therapeutic Uses
5.	Benzoic Acid (Potassium Benzoate)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Phosphodiesterase 5 Inhibitors
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Acetic Acid (Vinegar)
10.	Glutamic Acid (Glutamate)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)