HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

tirucallane

from Simarouba amara (Simaroubaceae); structure in first source

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - tirucallane: 6

Experts

1.	Chen, Ruo-Yun: 1 article (08/2020)
2.	Fu, Jia: 1 article (08/2020)
3.	Kang, Jie: 1 article (08/2020)
4.	Li, Bao-Ming: 1 article (08/2020)
5.	Li, Chang-Kang: 1 article (08/2020)
6.	Wang, Hong-Qing: 1 article (08/2020)
7.	Xie, Jun: 1 article (08/2020)
8.	Ding, Gang: 1 article (03/2020)
9.	Kuang, Yi: 1 article (03/2020)
10.	Liu, Bing: 1 article (03/2020)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2016 - "One of the tirucallane triterpenes exhibited significant cytotoxic activities against four human cancer cell lines (HL60, HeLa, HepG2, and SMMC-7721) in vitro. " 03/09/2020 - "Three new inositol angelate compounds (1-3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC50 value at 8.4 and 13.2 μM. "
2.	Neuroblastoma 09/01/2006 - "Fifteen triterpene acids, viz., seven of the beta-boswellic acids (ursane-type) (1-7), two of the alpha-boswellic acids (oleanane-type) (8, 9), two of the lupeolic acids (lupane-type) (10, 11), and four of the tirucallane-type (12-14, 16), and two cembrane-type diterpenes (17, 18), isolated from the MeOH extract of the resin of Boswellia carteri (Burseraceae), together with a triterpene acid 15 (the acetyl derivative of 14), were examined for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and on activation of (+/-)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, and cytotoxic activities against three human neuroblastoma cell lines, IMR-32, NB-39, and SK-N-SH in vitro. "
3.	Inflammation (Inflammations) 08/01/2020 - "Although the naturally-derived tirucallane-type triterpenoids were found in a small amount, the kind of compounds showed various structures, which consist of apo-type, linear said-chain-type and cyclolike said-chain-type and broad bioactivities, such as cytotoxicity, anti-inflammation, antioxidation and anti-plasmin, etc. This paper summarized origins, structures and bioactivities of tirucallane-type triterpenoids in recent ten years. "
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2019 - "New tirucallane triterpenoids from Picrasma quassioides with their potential antiproliferative activities on hepatoma cells."
5.	Breast Neoplasms (Breast Cancer) 07/01/2023 - "Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells."

Related Drugs and Biologics

1.	Triterpenes
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Inositol (Myoinositol)
4.	Fibrinolysin
5.	Diterpenes
6.	Alkaloids
7.	Acids
8.	lupane
9.	oleanane
10.	1,3- dihydroxy- 4,4,5,5- tetramethyl- 2- (4- carboxyphenyl)tetrahydroimidazole (NOR 1)