SB-271258

structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Bell, D: 1 article (09/2006)
2.	McDermott, B J: 1 article (09/2006)

1.	Cardiomegaly (Heart Hypertrophy) 09/01/2006 - "In conclusion, these data imply that cardiac hypertrophy associated with chronic administration of rosiglitazone in dogs in previous in vivo studies might be partly attributable to production of the metabolite SB-271258 since this metabolite was shown to elicit trophic effects directly on rat cardiomyocytes."
2.	Hypertrophy 09/01/2006 - "The hypothesis that SB-271258 had potential to initiate cardiomyocyte hypertrophy or to modify responses elicited by other hypertrophic stimuli was tested in an in vitro bioassay utilising adult rat ventricular cardiomyocytes. " 09/01/2006 - "In re-differentiated cardiomyocytes, a model of relevance to established hypertrophy, SB-271258 (1 nM-1 microM) elicited a marked trophic effect per se, as evidenced by the maximum increase (at 100 nM), in protein synthesis of 24.5%. "