oligonol

a product emanating from the oligomerization of polyphenols, typically proanthocyanidin from a variety of fruits (grapes, apples, persimmons, etc.) and contains catechin-type monomers and proanthocyanidin oligomers

Networked: 46 relevant articles (8 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fujii, Hajime: 13 articles (11/2017 - 01/2006)
2.	Yokozawa, Takako: 12 articles (01/2019 - 10/2010)
3.	Park, Chan Hum: 8 articles (12/2018 - 10/2010)
4.	Noh, Jeong Sook: 5 articles (12/2017 - 10/2010)
5.	Sun, Buxiang: 5 articles (01/2009 - 01/2006)
6.	Lee, Hyangkyu: 4 articles (04/2022 - 01/2014)
7.	Chang, Sue-Joan: 4 articles (01/2019 - 04/2016)
8.	Liu, Hung-Wen: 4 articles (01/2019 - 04/2016)
9.	Choi, Jae Sue: 4 articles (11/2017 - 02/2015)
10.	Nishioka, Hiroshi: 4 articles (11/2013 - 03/2007)

Related Diseases

1.	Insulin Resistance 06/16/2015 - "Oligonol may have beneficial effects in lipid metabolism and insulin resistance in the liver." 06/16/2015 - "Oligonol restored insulin sensitivity, as was determined by the phosphorylation states of IRS-1. " 10/01/2016 - "Flavanol-rich lychee fruit extract, oligonol, exhibited anti-obesity property in vitro and in vivo; however, the effects of oligonol on peripheral lipid metabolism and insulin sensitivity have not been fully investigated. " 04/01/2016 - "In conclusion, oligonol reduced fasting glucose level, improved insulin sensitivity, suppressed inflammatory responses, and upregulated metabolic regulators involved in mitochondrial biogenesis, thereby leading to protection against diabetes-induced kidney damage. " 10/01/2016 - "Oligonol reduced intracellular lipid contents in liver and skeletal muscle and suppressed inflammatory markers, thereby alleviating HFD-induced insulin resistance."
2.	Inflammation (Inflammations) 04/01/2015 - "These results indicate that oligonol has protective activity against oxidative stress-induced inflammation. " 04/01/2015 - "Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell." 02/01/2015 - "This article summarizes recent work whether oligonol has an ameliorative effect on diabetic indices and renal disorders associated with gluco-lipotoxicity-mediated oxidative stress, inflammation, and apoptosis in db/db mice with diabetes. " 08/01/2007 - "Oligonol (60mg/kg) significantly modulated the extent of inflammation scores in the eye of SAMP8 mice. " 08/01/2007 - "Thus Oligonol treatment to SAMP8 mice modulated the severity of infection-dependent inflammation, prolonged life-span and significantly improved locomotive activity indicating potential benefit to aging-associated diseases such as Alzheimer's or Parkinson's diseases. "
3.	Obesity 06/16/2015 - "Several studies suggest that Oligonol has an anti-obesity effect. " 10/01/2016 - "Flavanol-rich lychee fruit extract, oligonol, exhibited anti-obesity property in vitro and in vivo; however, the effects of oligonol on peripheral lipid metabolism and insulin sensitivity have not been fully investigated. " 09/20/2017 - "Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity properties, suggesting it could be a proper supplement for attenuating muscle loss. " 01/01/2014 - "These results suggest that Oligonol may be a potent regulator of obesity by repressing major adipogenic genes through inhibition of the Akt signaling pathway, which induces the inhibition of lipid accumulation, ultimately inhibiting adipogenesis. " 06/16/2015 - "Since obesity is tightly associated with insulin resistance, we investigated a possible remission effect of Oligonol on lipid accumulation and insulin resistance in human hepatic HepG2 cells. "
4.	Infections 12/01/2013 - "In this study, we examined the inhibitory effect of Oligonol, a purified phenolic extract from lychee fruit, on betanodavirus infection in fish cells. " 08/01/2007 - "Thus Oligonol treatment to SAMP8 mice modulated the severity of infection-dependent inflammation, prolonged life-span and significantly improved locomotive activity indicating potential benefit to aging-associated diseases such as Alzheimer's or Parkinson's diseases. " 08/01/2007 - "The ability of Oligonol to affect infection-dependent eye inflammation, locomotion and longevity in senescence-accelerated prone mice (SAMP8) (a model of senescence acceleration and geriatric disorders with increased oxidative stress and neuronal deficit) was investigated. " 08/01/2007 - "Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol." 02/01/2016 - "In response to influenza virus infection of A549 cells, oligonol treatment significantly up-regulated SIRT1 expression and down-regulated viral hemagglutinin expression. "
5.	Non-alcoholic Fatty Liver Disease 11/01/2022 - "The Efficacy of Oligonol in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blinded Placebo-Controlled Trial." 11/01/2022 - "The aim of this study was to evaluate the effects of oligonol in patients with nonalcoholic fatty liver disease (NAFLD). " 07/16/2022 - "Our results also support the beneficial and complementary role of oligonol in treating NAFLD." 11/01/2022 - "Discussion: Oligonol has not shown a significant therapeutic effect in NAFLD. " 11/01/2022 - "Methods: Adult patients with NAFLD defined by magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) ≥11% were enrolled and then randomly assigned to receive either oligonol or placebo capsules. "

Related Drugs and Biologics

1.	Lipids
2.	Glucose (Dextrose)
3.	Polyphenols
4.	Proteins (Proteins, Gene)
5.	Insulin (Novolin)
6.	Caspase 3 (Caspase-3)
7.	bcl-2-Associated X Protein (bcl 2 Associated X Protein)
8.	Cytochromes c (Cytochrome c)
9.	Cytokines
10.	Palmitates

Related Therapies and Procedures

1.	Oral Administration
2.	Phototherapy (Light Therapy)