liphagal

selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Colonic Neoplasms (Colon Cancer) 01/01/2019 - "In this study, we demonstrated that siphonodictyal B inhibits several kinases such as CDK4/6, CDK7, and PIM2 in addition to PI3K in vitro and that siphonodictyal B exhibits more potent cytotoxic effects than liphagal against human colon cancer cell lines. "
2.	Neoplasms (Cancer) 01/01/2019 - "Liphagal, isolated from the marine sponge Aka coralliphaga, exhibits phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitory activity and cytotoxic effects in human cancer cells. "

1.	Phosphotransferases (Kinase)
2.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)