|1.||Barochia, Amisha: 1 article (11/2011)|
|2.||Eichacker, Peter Q: 1 article (11/2011)|
|3.||Li, Yan: 1 article (11/2011)|
|4.||Natanson, Charles: 1 article (11/2011)|
|5.||Cui, Xizhong: 1 article (11/2011)|
|6.||Qiu, Ping: 1 article (11/2011)|
|7.||Wheeler, Arthur P: 1 article (09/2006)|
|8.||Paz, Harold L: 1 article (09/2006)|
|9.||Edens, Tonya R: 1 article (09/2006)|
|10.||Russell, James A: 1 article (09/2006)|
11/01/2011 - "An overview of the biology of TNF and experimental data implicating TNF as a key mediator in sepsis pathogenesis; a review of the earlier clinical experience with anti-TNF therapies demonstrating that when examined across 12 trials, these agents had a highly consistent overall effect which although not reaching significance, was on the side of benefit; a review of data showing that sepsis-associated risk of death may influence the efficacy of anti-inflammatory agents like anti-TNF ones and a review of the rational and clinical experience to date with AZD9773 and its precursor, CytoFab. "
09/01/2006 - "Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis."
09/01/2006 - "CytoFab is well tolerated in patients with severe sepsis, effectively reducing serum and BAL TNF-alpha and serum IL-6 concentrations and increasing the number of ventilator-free and ICU-free days at day 28."
09/01/2006 - "The number of shock-free days did not differ between CytoFab and placebo (10.7 vs. 9.4, respectively) (p = .270). "
09/01/2006 - "This trial was designed to evaluate the safety and effectiveness of polyclonal ovine anti-TNF fragment antigen binding (Fab) fragments (CytoFab) on plasma TNF-alpha, interleukin-6 (IL-6), and interleukin-8 (IL-8) concentrations and the number of shock-free and ventilator-free days in severely septic patients. "
|1.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|2.||Anti-Inflammatory Agents (Anti-Inflammatories)
|3.||Interleukin-8 (Interleukin 8)
|4.||Interleukin-6 (Interleukin 6)
|5.||Immunoglobulin Fab Fragments
|1.||Mechanical Ventilators (Ventilator)