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3,6-dihydroxy-7-fluorocholanoic acid

prevents 17alpha-ethynylestradiol-induced cholestasis in rats; structure in first source

Also Known As:

3alpha,6alpha-dihydroxy-7alpha-fluoro-5beta-cholanoate; UPF 680; UPF-680; UPF680

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Bile Acids and Salts: 11432
      - Cholic Acids: 14
        Deoxycholic Acid: 963
        3,6-dihydroxy-7-fluorocholanoic acid: 1
    - Cholanes
      - Cholic Acids: 14
        Deoxycholic Acid: 963
        3,6-dihydroxy-7-fluorocholanoic acid: 1

Experts

1.	Asciutti, Stefania: 1 article (07/2006)
2.	Baldoni, Monia: 1 article (07/2006)
3.	Camaioni, Emidio: 1 article (07/2006)
4.	Castellani, Danilo: 1 article (07/2006)
5.	Clementi, Mattia: 1 article (07/2006)
6.	Clerici, Carlo: 1 article (07/2006)
7.	Fiorucci, Stefano: 1 article (07/2006)
8.	Giuliano, Vittorio: 1 article (07/2006)
9.	Mazzocchi, Alessandro: 1 article (07/2006)
10.	Morelli, Antonio: 1 article (07/2006)

Related Diseases

1.	Cholestasis 07/15/2006 - "Treatment with UDCA and UPF-680 reversed chronic cholestasis induced by 17EE; in this model, UDCA had no effect on bile flow in contrast to UPF-680, which significantly increased bile flow. " 07/15/2006 - "In conclusion, UPF-680 prevented 17EE-induced cholestasis and enriched the biliary bile acid pool with less detergent and cytotoxic bile acids. " 07/15/2006 - "Acute rat biliary fistula and chronic cholestasis induced by 17alpha-ethynyl-estradiol (17EE) models were used to study and compare the effects of UPF-680 (dose range 0.6-6.0 micromol/kg min) with UDCA on bile flow, biliary bicarbonate (HCO(3)(-)), lipid output, biliary bile acid composition, hepatic enzymes and organic anion pumps. "
2.	Biliary Fistula 07/15/2006 - "Acute rat biliary fistula and chronic cholestasis induced by 17alpha-ethynyl-estradiol (17EE) models were used to study and compare the effects of UPF-680 (dose range 0.6-6.0 micromol/kg min) with UDCA on bile flow, biliary bicarbonate (HCO(3)(-)), lipid output, biliary bile acid composition, hepatic enzymes and organic anion pumps. "

Related Drugs and Biologics

1.	Anion Transport Proteins
2.	Lipids
3.	Enzymes
4.	Bile Acids and Salts (Bile Acids)
5.	Bicarbonates (Hydrogen Carbonate)
6.	Detergents (Detergent)