1- (methylimino- N- oxy)- 6- (2- morpholinoethoxy)- 3- phenyl- 1H- indene- 2- carboxylic acid ethyl ester

has weak adipogenic effects; structure in first source

Also Known As:

KR 62980; KR-62980; KR-63198; KR62980

Networked: 8 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester: 8
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - 1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester: 8
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - 1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester: 8

Experts

1.	Ahn, Jin Hee: 6 articles (04/2014 - 08/2006)
2.	Cheon, Hyae Gyeong: 4 articles (02/2011 - 08/2006)
3.	Bae, Myung Ae: 3 articles (04/2014 - 11/2009)
4.	Kim, Ki Young: 3 articles (02/2011 - 08/2006)
5.	Hong, Jeong-Ho: 2 articles (03/2010 - 11/2009)
6.	Hwang, Eun Sook: 2 articles (03/2010 - 11/2009)
7.	Yoo, Sung-Eun: 2 articles (03/2010 - 11/2009)
8.	Kim, Sung Soo: 2 articles (08/2006 - 08/2006)
9.	Han, Doo Hee: 1 article (05/2015)
10.	Kim, Dong Young: 1 article (05/2015)

Related Diseases

1.	Allergic Rhinitis 05/01/2015 - "The present study was aimed to investigate the effects of KR62980 on nasal symptoms and immunopathological profiles in allergic nasal mucosa in murine allergic rhinitis model. " 05/01/2015 - "Antiallergic Function of KR62980, a Peroxisome Proliferator-Activated Receptor-γ Agonist, in a Mouse Allergic Rhinitis Model." 03/15/2010 - "In conclusion, a novel PPARgamma ligand, KR62980, suppresses in vitro Th2 cell differentiation and attenuates in vivo OVA-induced airway inflammation, suggesting a beneficial role for KR62980 in the treatment of allergic asthma and allergic rhinitis."
2.	Lung Neoplasms (Lung Cancer) 09/01/2007 - "In the present study, we elucidated the apoptotic mechanism of PPARgamma activation in human lung cancers by using a novel PPARgamma agonist, 1-(trans-methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-(1H-indene-2-carboxylic acid ethyl ester (KR-62980), and rosiglitazone. "
3.	Ischemia 02/04/2011 - "In the present study, we investigated the effects of KR-62980, a new PPARγ agonist, and rosiglitazone on the neuronal cell death induced by chemical ischemia-reperfusion in SK-N-SH cells and their underlying molecular mechanisms. " 02/04/2011 - "Neuroprotective effects of KR-62980, a new PPARγ agonist, against chemical ischemia-reperfusion in SK-N-SH cells." 02/04/2011 - "Our results demonstrate that two PPARγ agonists, KR-62980 and rosiglitazone, inhibited chemical ischemia-reperfusion-induced neuronal cell death by PPARγ-mediated anti-apoptotic and anti-oxidant mechanisms related to PTEN suppression and ERK phosphorylation."
4.	Breast Neoplasms (Breast Cancer) 08/28/2006 - "These results suggest that PPARgamma activation may result in the inhibition of cell proliferation and/or induction of cell differentiation depending on the type of PPARgamma agonists, and that KR-62980 may be useful in breast cancer therapy by inducing apoptosis." 08/28/2006 - "In the present study, we investigated the effects of two structurally different PPARgamma agonists, rosiglitazone and KR-62980 on MCF-7 breast cancer cells. "
5.	Weight Gain 04/01/2014 - "These results suggest that cICDH may be one of the targets of KR-62980 responsible for weight gain and adipogenesis." 08/14/2006 - "Treatment of high fat diet-induced C57BL/6J mice with KR-62980 for 14 days reduced plasma glucose levels with little side effects with regard to weight gain, cardiac hypertrophy and hepatotoxicity. "

Related Drugs and Biologics

1.	Rosiglitazone (Avandia)
2.	PPAR gamma
3.	Esters
4.	Carboxylic Acids
5.	indene
6.	Ligands
7.	Interleukin-17 (Interleukin 17)
8.	Anti-Allergic Agents (Antiallergic Agents)
9.	Cytokines
10.	Peroxisome Proliferator-Activated Receptors (PPAR)

Related Therapies and Procedures

1.	Therapeutics