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NSC-87877

potent Shp2 (nonreceptor protein tyrosine phosphatase) inhibitor; structure in first source

Also Known As:

8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid

Networked: 15 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - NSC-87877: 15

Experts

1.	Ding, Xu: 2 articles (10/2018 - 01/2015)
2.	Liu, Xiao-Dan: 2 articles (10/2018 - 01/2015)
3.	Shen, Yan: 2 articles (04/2014 - 10/2012)
4.	Sun, Yang: 2 articles (04/2014 - 10/2012)
5.	Xu, Qiang: 2 articles (04/2014 - 10/2012)
6.	Choi, Wahn Soo: 2 articles (01/2011 - 01/2011)
7.	Kim, Bokyung: 2 articles (01/2011 - 01/2011)
8.	Lee, Chang-Kwon: 2 articles (01/2011 - 01/2011)
9.	Lee, Hwan Myung: 2 articles (01/2011 - 01/2011)
10.	Lee, Seung Hyun: 2 articles (01/2011 - 01/2011)

Related Diseases

1.	Hyperalgesia 05/01/2012 - "SHP2 siRNA led to similar effects as the NSC-87877 and SIRPα1 antibody treatments, except it prevented the allodynia-associated spinal SHP2 expression. " 05/01/2012 - "Intrathecal administration of NSC-87877 (an SHP2 antagonist; 1, 10, or 100μM/rat) and SIRPα1-neutralizing antibodies (1, 10, or 30μg/rat) suppressed spinal nerve ligation-induced allodynia, spinal SHP2 and NR2B phosphorylation, and SHP2/phosphorylated SHP2-PSD-95 and PSD-95-NR2B/phosphorylated NR2B coprecipitation. " 10/01/2018 - "Intrathecal blockade of SHP2 phosphorylation using a SHP2 protein tyrosine phosphatase inhibitor NSC-87877, or knockdown of SHP2 by intrathecal delivery of small interfering RNA (siRNA), ameliorates mechanical allodynia and heat hyperalgesia in nIN-IN rats. " 01/01/2015 - "Blockade of SHP2 phosphorylation in the spinal dorsal horn using a potent SHP2 protein tyrosine phosphatase inhibitor NSC-87877, or knockdown of spinal SHP2 by intrathecal delivery of SHP2 siRNA, not only prevents BDNF-mediated GluN2B-NMDA receptors activation as well as spinal LTP induction and pain allodynia elicitation in intact rats, but also reduces the SNL-evoked GluN2B-NMDA receptors up-regulation and spinal LTP occlusion, and ultimately alleviates pain allodynia in neuropathic rats. "
2.	Non-alcoholic Fatty Liver Disease 01/01/2022 - "Furthermore, administration of NSC-87877 to murine models of nonalcoholic steatohepatitis was associated with improved survival and decreased markers of injury after hepatectomy. "
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/01/2014 - "In this study, we examined the effect of NSC-87877, a potent Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) inhibitor, on experimental autoimmune encephalomyelitis (EAE) and elucidated its unique mechanism of action. "
4.	Neointima 01/01/2011 - "Oral administration of NSC-87877 (10 mg/kg) significantly suppressed neointima formation in a rat model of carotid artery injury. " 01/01/2011 - "Oral administration of NSC-87877 (10 mg/kg) significantly suppressed neointima formation in a rat model of carotid artery injury. "
5.	Carotid Artery Injuries 01/01/2011 - "Oral administration of NSC-87877 (10 mg/kg) significantly suppressed neointima formation in a rat model of carotid artery injury. " 01/01/2011 - "Oral administration of NSC-87877 (10 mg/kg) significantly suppressed neointima formation in a rat model of carotid artery injury. "

Related Drugs and Biologics

1.	Protein Tyrosine Phosphatases
2.	Small Interfering RNA (siRNA)
3.	p38 Mitogen-Activated Protein Kinases
4.	Brain-Derived Neurotrophic Factor (BDNF)
5.	T-Cell Antigen Receptors (T-Cell Receptor)
6.	Phosphoric Monoester Hydrolases (Phosphatases)
7.	Indicators and Reagents (Reagents)
8.	Immunoglobulin G (IgG)
9.	Collagen
10.	Antibodies

Related Therapies and Procedures

1.	Hepatectomy
2.	Oral Administration
3.	Therapeutics
4.	Ligation