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4-(1-phenylethyl)-1,3-benzenediol

a tyrosinase inhibitor with skin-lightening activity; structure in first source

Also Known As:

phenylethyl resorcinol

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Resorcinols: 4
        4-(1-phenylethyl)-1,3-benzenediol: 6
        Benzhydryl Compounds
        4-(1-phenylethyl)-1,3-benzenediol: 6

Experts

1.	Aerts, Olivier: 1 article (03/2021)
2.	Dendooven, Ella: 1 article (03/2021)
3.	Herman, Anne: 1 article (03/2021)
4.	Mairlot, Margaux: 1 article (03/2021)
5.	Cho, Jae Youl: 1 article (05/2019)
6.	Kang, Mingyeong: 1 article (05/2019)
7.	Kim, Jangsoon: 1 article (05/2019)
8.	Kwon, Kitae: 1 article (05/2019)
9.	Lee, Jongsung: 1 article (05/2019)
10.	Oh, Sae Woong: 1 article (05/2019)

Related Diseases

1.	Allergic Contact Dermatitis 03/21/2021 - "Three additional cases of facial allergic contact dermatitis from the powerful pigment-lightening agent phenylethyl resorcinol." 11/21/2023 - "Cosmetovigilance for infrequent allergens in Spain using a national online registry: The example of allergic contact dermatitis caused by phenylethyl resorcinol." 10/01/2016 - "Allergic contact dermatitis caused by phenylethyl resorcinol, a skin-lightening agent contained in a sunscreen." 11/01/2013 - "Allergic contact dermatitis caused by phenylethyl resorcinol [4-(1-phenylethyl)-1,3-benzenediol], a skin-lightening agent in cosmetics."
2.	Hyperpigmentation 05/01/2019 - "These data indicate that the anti-melanogenic activity of phenylethyl resorcinol is mediated by activation of p44/42 MAPK, indicating that phenylethyl resorcinol may be a potential therapeutic agent for treating hyperpigmentation skin disorders." 10/01/2016 - "Bifunctional alpha-bisabolol and phenylethyl resorcinol/TiO2 hybrids were prepared to apply in cosmetic fields, particularly in anti-ageing and hyperpigmentation treatment. "
3.	Microphthalmos 05/01/2019 - "Although phenylethyl resorcinol decreased mRNA levels of tyrosinase and tyrosinase-related protein (TRP)-2, it did not affect mRNA levels of melanogenic gene microphthalmia-associated transcriptional factor (MITF) or TRP-1. "
4.	Melanoma (Melanoma, Malignant) 05/01/2019 - "To investigate effects of phenylethyl resorcinol as one resorcinol derivative on melanogenesis and its mechanisms using B16F10 mouse melanoma cells and human epidermal melanocytes. "
5.	Hypersensitivity (Allergy) 11/21/2023 - "A systematic search in the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC) database was performed to identify patients with positive patch test to phenylethyl resorcinol or cosmetics that contains it between June 2018 and January 2023. "

Related Drugs and Biologics

1.	Cosmetics
2.	Monophenol Monooxygenase (Tyrosinase)
3.	Sunscreening Agents (Sunscreens)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Allergens
7.	resorcinol (resorcin)
8.	interferon tau
9.	bisabolol (levomenol)