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5,5'-dibromo-1,1-bis(3'-indolyl)methane

Also Known As:

5,5'-dibromoDIM

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 5,5'-dibromo-1,1-bis(3'-indolyl)methane: 3

Experts

1.	Safe, Stephen: 3 articles (03/2010 - 05/2006)
2.	Abdelrahim, Maen: 2 articles (03/2010 - 07/2008)
3.	Chintharlapalli, Sudhakar: 2 articles (03/2010 - 07/2008)
4.	Cho, Hyun-Tae: 1 article (03/2010)
5.	Cho, Nam-Pyo: 1 article (03/2010)
6.	Cho, Sung-Dae: 1 article (03/2010)
7.	Choi, Eun-Sun: 1 article (03/2010)
8.	Choi, Hong Seok: 1 article (03/2010)
9.	Choi, Kyeong-Hee: 1 article (03/2010)
10.	Jung, Ji-Youn: 1 article (03/2010)

Related Diseases

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/01/2010 - "In this study, we investigated whether 5,5'-dibromoDIM inhibits the proliferation of KB and YD-10B oral squamous carcinoma cell lines. "
2.	Colonic Neoplasms (Colon Cancer) 03/01/2010 - "We developed a series of synthetic ring-substituted DIM analogs including 5,5'-dibromoDIM that exhibited better inhibitory activity in breast and colon cancer cells than DIM. " 07/01/2008 - "5,5'-DibromoDIM (30 mg/kg/d) also inhibited tumor growth and induced p21 in athymic nude mice bearing RKO cells as xenografts, showing that ring-substituted DIM such as 5,5'-dibromoDIM represent a novel class of mechanism-based drugs for clinical treatment of colon cancer." 07/01/2008 - "In colon cancer cells, 5,5'-dibromoDIM decreased cell proliferation and inhibited G(0)-G(1)- to S-phase progression, and this was accompanied by induction of the cyclin-dependent kinase inhibitor p21 in HT-29 and RKO colon cancer cells. "
3.	Neoplasms (Cancer) 07/01/2008 - "We have developed a series of synthetic symmetrical ring-substituted DIM analogues, including 5,5'-dibromoDIM, which are more potent than DIM as inhibitors of cancer cell and tumor growth. " 07/01/2008 - "5,5'-DibromoDIM (30 mg/kg/d) also inhibited tumor growth and induced p21 in athymic nude mice bearing RKO cells as xenografts, showing that ring-substituted DIM such as 5,5'-dibromoDIM represent a novel class of mechanism-based drugs for clinical treatment of colon cancer."
4.	Mouth Neoplasms (Oral Cancer) 03/01/2010 - "5,5'-dibromoDIM decreased the cell survival and inhibited the growth of oral cancer cells. " 03/01/2010 - "These results highlight 5,5'-dibromoDIM as an important chemopreventive agent for the clinical treatment of oral cancer through the p38 mitogen-activated protein kinase pathway."
5.	Breast Neoplasms (Breast Cancer) 05/18/2006 - "Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM."

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase Inhibitor p21
2.	p38 Mitogen-Activated Protein Kinases
3.	1,1-bis(3'-indolyl)methane