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uncialamycin

enediyne antibiotic; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Anthracenes: 12
        Anthrones: 12
        Anthraquinones: 788
        uncialamycin: 3
- Quinones: 434
  - Anthraquinones: 788
    - uncialamycin: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - Anthrones: 12
      - Anthraquinones: 788
        uncialamycin: 3

Experts

1.	Adhikari, Ajeeth: 1 article (06/2021)
2.	Ge, Huiming: 1 article (06/2021)
3.	Hindra,: 1 article (06/2021)
4.	Huang, Tingting: 1 article (06/2021)
5.	Luo, Jun: 1 article (06/2021)
6.	Shen, Ben: 1 article (06/2021)
7.	Teijaro, Christiana N: 1 article (06/2021)
8.	Yan, Xiaohui: 1 article (06/2021)
9.	Yang, Dong: 1 article (06/2021)
10.	Cardarelli, Pina: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 06/04/2021 - "Uncialamycin (UCM) belongs to the anthraquinone-fused subfamily of 10-membered enediyne natural products that exhibits an extraordinary cytotoxicity against a wide spectrum of human cancer cell lines. " 01/01/2019 - "The potency and mechanism of action of this uncialamycin class of enediyne antitumor antibiotics make them attractive payloads in ADC-based cancer therapy." 01/01/2019 - "Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy." 01/01/2019 - "Uncialamycin analogs were evaluated as potential cytotoxic agents in an antibody-drug conjugate (ADC) approach to treating human cancer. "
2.	Cystic Fibrosis (Mucoviscidosis) 11/10/2005 - "Uncialamycin (1) exhibits potent in vitro antibacterial activity against gram-positive and gram-negative human pathogens, including Burkholderia cepacia, a major cause of morbidity and mortality in patients with cystic fibrosis."

Related Drugs and Biologics

1.	Immunoconjugates (Immunoconjugate)
2.	Cytotoxins (Cytolysins)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Anthraquinones

Related Therapies and Procedures

1.	Therapeutics