3- (4- dimethylaminophenyl)- N- hydroxy- 2- propenamide

05/01/2012 - "Cell cycle analysis revealed that the gowth inhibitory effects of IN-2001 might be attributed to cell cycle arrest at G0/G1 and/or G2/Mphase and subsequent apoptosis in human breast cancer cells. "
05/01/2012 - "IN-2001 effectively inhibited cellular HDAC activity (IC50 = 0.585 nM) in MDA-MB-231 human breast cancer cells. "
05/15/2006 - "In human breast cancer cells (MCF-7, T47D, MDA-MB-231, and MDA-MB-468), IN-2001 induced cell cycle arrest at G(2)-M phase through up-regulation of p21(WAF1) and p27(KIP1) and eventually caused apoptosis. "
05/15/2006 - "IN-2001 effectively inhibited cellular HDAC activity (IC(50), 5.42 nmol/L) in MCF-7 human breast cancer cells. "
05/01/2012 - "Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer."

05/15/2006 - "IN-2001 suppressed mammary tumor growth in MMTV/c-Neu transgenic mice and also showed higher apoptotic index and lower lymphatic invasion compared with controls. "
05/01/2012 - "Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer."
01/01/2012 - "In T47D human breast cancer cells showed anti-tumor activity of IN-2001 and the growth inhibitory effects of IN-2001 were related to the cell cycle arrest and induction of apoptosis. "
01/01/2012 - "Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer."
05/01/2012 - "In summary, our data suggest that this histone deacetylase inhibitor, IN-2001, is a novel promising therapeutic agent with potent antitumor effects against human breast cancers. "