3beta,6beta,16beta- trihidroxilup- 20(29)- ene
from the flowers of Combretum leprosum; structure in first source
Also Known As:
3beta 6beta,16beta-trihydroxylup-20(29)-ene; TH-terpene
relevant articles (0 outcomes,
Bio-Agent Context: Research Results
|1. ||Pain (Aches)
- "The present study examined the antinociceptive effects of the ethanolic extract (EE) and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in chemical and thermal behavioural models of pain in mice.
- "Furthermore, the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene (1-30 mg/kg), given p.o., 1 h prior to testing, also produced dose-related inhibition of glutamate-induced pain, with a mean ID50 value of 5.6 mg/kg. When assessed in a thermal model of pain, the EE (10-300 mg/kg, p.o.) and fentanyl (100 microg/kg, s.c.) caused a significant and marked increase in the latency response on the hot-plate test (50 degrees C).
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