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IGN 311

under phase I/II clinical trials for treating cancer

Also Known As:

HuABL-364; IGN 312; IGN-311; IGN-312; IGN311; IGN312

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        IGN 311: 4
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        IGN 311: 4
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        IGN 311: 4

Experts

1.	Kircheis, Ralf: 2 articles (06/2007 - 12/2006)
2.	Halanek, N: 1 article (05/2009)
3.	Kircheis, R: 1 article (05/2009)
4.	Nechansky, A: 1 article (05/2009)
5.	Siegl, P: 1 article (05/2009)
6.	Szolar, O H J: 1 article (05/2009)
7.	Wiederkum, S: 1 article (05/2009)
8.	Zinoecker, I: 1 article (05/2009)
9.	Amon, Sabine: 1 article (06/2007)
10.	Antes, Bernhard: 1 article (06/2007)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2006 - "These data indicate that tumor cell growth inhibition by IGN311 cannot solely be accounted for by invoking cellular and humoral immunological mechanisms. " 12/01/2006 - "Treatment with IGN311 was associated with a down-regulation of ErbB1 in the excised tumor tissue. " 12/01/2006 - "IGN311 inhibited the growth of tumors derived from A431 cells xenografted in nude mice. " 12/01/2006 - "Here, we tested whether binding of IGN311 to growth factor receptors is relevant also to inhibition of tumor growth in vivo. " 12/01/2006 - "A direct effect on signaling via binding to Lewis Y glycosylated growth factor receptors on tumor cells is also likely to contribute to the therapeutic effect of IGN311 in vivo."
2.	Breast Neoplasms (Breast Cancer) 05/01/2009 - "To demonstrate the functionality of its Fc-region, the capacity of IGN311 to mediate complement dependent cytotoxicity (CDC) against human breast cancer cells was evaluated. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Therapeutic Uses
3.	Growth Factor Receptors
4.	Proteins (Proteins, Gene)
5.	Immunoglobulin G (IgG)
6.	Complement System Proteins (Complement)
7.	Carbohydrates
8.	Antigens

Related Therapies and Procedures

1.	Therapeutics