|1.||Zhou, Zhi-feng: 1 article (02/2010)|
|2.||Liu, Peng: 1 article (02/2010)|
|3.||Jiang, Jian-ming: 1 article (02/2010)|
|4.||Baldan, Helen M: 1 article (09/2007)|
|5.||Machado, Rosângela G P: 1 article (09/2007)|
|6.||De Rosa, Helene J: 1 article (09/2007)|
|7.||Ximenes, Valdecir F: 1 article (09/2007)|
|8.||Brunetti, Iguatemy L: 1 article (09/2007)|
|9.||Jun, Sun Hee: 1 article (01/2007)|
|10.||Kim, Jin Q: 1 article (01/2007)|
|1.||Body Weight (Weight, Body)
09/01/2007 - "Since these hepatotoxic events have been associated with INH metabolites, the study aimed to measure the area under curve (AUC) parameter for INH and its metabolites acetylisoniazid (AcINH), hydrazine (Hz) and acetylhydrazine (AcHz), when groups of rats were pre-treated for 21 days with INH alone or in combination with RMP and/or PYR, in the following amounts per kg body weight: INH 100 mg; INH 100 mg + RMP 100 mg; INH 100 mg + PYR 350 mg; INH 100 mg + PYR 350 mg + RMP 100 mg. It was found that co-administration of RMP, PYR and RMP + PYR caused a significant decrease in the AUC for INH. "
07/01/1985 - "Pretreatment of rats with 150 mg per kg of cimetidine significantly decreased the extent of hepatocellular necrosis produced by 100 mg per kg of acetylhydrazine and the formation of 14CO2 from [14C]acetylisoniazid. "
05/01/1980 - "The changes in the metabolism of isoniazid, acetylisoniazid and acetylhydrazine effected by various pretreatments paralleled changes in the severity of the hepatic necrosis caused by the compounds. "
07/01/1985 - "To test this hypothesis, we studied the effect of cimetidine on acetylhydrazine-induced hepatocellular necrosis in rats and the formation of 14CO2 from [14C]acetylisoniazid, which provides an indirect assessment of the fraction of a dose of isoniazid metabolized via the toxifying pathway. "
01/01/1989 - "The results of the experiments with use of isoniazid and its metabolites showed that in the liver of rats isoniazid induced albuminous degeneration with stroma inflammation and hepatocyte necrosis, monoacetylhydrazine induced fatty hepatosis, acetylisoniazid induced fatty hepatosis with stroma inflammation and hepatocyte necrosis and isonicotinic acid induced granular degeneration. "
03/01/1994 - "Twenty patients, 1 through 13 years of age from Pediatric Tuberculosis Clinic of All India Institute of Medical Sciences, New Delhi, suffering from pulmonary primary complex (PPC) were investigated for serum and urine concentrations of isoniazid (INH) and acetylisoniazid (AcINH). "
01/01/2007 - "Here, we describe a method that can rapidly and simultaneously measure the blood concentrations of four anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide, and ethambutol) and two major metabolic ratios (acetylisoniazid/isoniazid and 25-desacetylrifampicin/rifampicin) using high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). "
|4.||Spinal Tuberculosis (Pott's Disease)
|2.||hydrazine (hydrazine dihydrochloride)
|5.||Isonicotinic Acids (Isonicotinic Acid)