|1.||Schousboe, Arne: 5 articles (02/2015 - 02/2005)|
|2.||Madsen, Karsten K: 4 articles (02/2015 - 05/2009)|
|3.||White, H Steve: 4 articles (07/2011 - 02/2005)|
|4.||Clausen, Rasmus P: 3 articles (07/2011 - 02/2005)|
|5.||Krogsgaard-Larsen, Povl: 3 articles (07/2011 - 02/2005)|
|6.||Larsson, Orla M: 2 articles (05/2009 - 02/2005)|
|7.||Hansen, Gert H: 1 article (02/2015)|
|8.||Danielsen, E Michael: 1 article (02/2015)|
|9.||Ebert, Bjarke: 1 article (07/2011)|
|10.||Poblete-Naredo, I: 1 article (06/2011)|
06/01/2011 - "The present study addresses the role of BGT1 in seizure control and the effect of EF1502 by developing and exploring a new mouse line lacking exons 3-5 of the BGT1 (slc6a12) gene. "
06/01/2011 - "In conclusion, the present results do not support a role for BGT1 in the control of seizure susceptibility and cannot provide a mechanistic understanding of the synergism that has been previously reported with tiagabine and EF1502."
05/01/2009 - "When combined with the GAT1 selective inhibitor tiagabine, EF1502 was found to possess a synergistic anti-convulsant action in the Frings audiogenic seizure-susceptible mouse model of reflex epilepsy. "
05/01/2009 - "In this study, the anti-convulsant effect of the GAT2/3 inhibitor SNAP-5114 was assessed in the Frings audiogenic seizure-susceptible mouse alone, and in combination with tiagabine and EF1502. "
02/01/2015 - "The simultaneous inhibition of synaptic and extrasynaptic GABA transporters using tiagabine and EF1502, respectively has been demonstrated to exert a synergistic anticonvulsant effect in several seizure models in mice. "
|2.||Partial Epilepsies (Epilepsy, Partial)
02/01/2005 - "In the present study, EF1502 was found to possess a broad-spectrum anticonvulsant profile in animal models of generalized and partial epilepsy. "
05/01/2009 - "These findings support anatomical evidence that GAT2/3 are most likely located at the synapse in close proximity to GAT1; whereas BGT-1 is located some distance away from the synapse and GAT1 and GAT2/3. Lastly, EF1502 and tiagabine were evaluated alone, and in combination, in the corneal kindled mouse model of partial epilepsy. "
|3.||Reflex Epilepsy (Photosensitive Epilepsy)
03/01/2010 - "It is suggested that the betaine-GABA transporter BGT1 should receive particular interest in this context as the GABA analogue EF 1502 (N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-4-(methylamino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol) has been shown to possess a novel anticonvulsant profile in animal models of epilepsy, involving the ability to inhibit GABA transport mediated by GAT1 and BGT1 at the same time."
|5.||4,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)
|6.||GABA-A Receptors (GABA(A) Receptor)
|7.||1- (2- (tris(4- methoxyphenyl)methoxy)ethyl)- 3- piperidinecarboxylic acid
|8.||4,5,6,7- tetrahydroisoxazolo(5,4- c)pyridin- 3- ol (THIP)
|9.||gamma-Aminobutyric Acid (GABA)
|10.||GABA-A Receptor Agonists