boranophosphate

boranophosphate-modified ss-siRNA can silence gene expression as well as native ds-siRNA, suggesting that boranophosphate-modified ss-siRNAs should be investigated as a potential new class of therapeutic agents

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shaw, Barbara Ramsay: 2 articles (05/2013 - 01/2008)
2.	Cheek, Marcus Adrian: 1 article (05/2013)
3.	Dobrikov, Mikhail I: 1 article (05/2013)
4.	Sharaf, Mariam L: 1 article (05/2013)
5.	Cheek, Marcus: 1 article (01/2008)
6.	Dobrikov, Mikhail: 1 article (01/2008)
7.	Moussa, Laura: 1 article (01/2008)
8.	Sharaf, Mariam: 1 article (01/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2008 - "Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators." 01/01/2008 - "We are investigating the use of boranophosphate (BP) analogues of RNA as promising candidates for enhancing the potential of three relatively new, gene-specific, anticancer strategies: (1) Tumor-targeted borane siRNA against a combination of genes that control metabolism and transduction; (2) Tumor-specific modified aptamers against prostate specific membrane antigen (PSMA) and ERB2 in breast cancer as delivery agents; and (3) Cancer cell obliteration by cell-specific radiation therapy: Boron-Neutron-Capture-Therapy."
2.	Hepatitis C 05/01/2013 - "Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design."
3.	Conversion Disorder (Astasia Abasia) 01/01/2023 - "Notably, it was suggested that the conversion reaction of a boranophosphate to a phosphorothioate diester proceeded with retention of the stereochemistry of the phosphorous center. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "We are investigating the use of boranophosphate (BP) analogues of RNA as promising candidates for enhancing the potential of three relatively new, gene-specific, anticancer strategies: (1) Tumor-targeted borane siRNA against a combination of genes that control metabolism and transduction; (2) Tumor-specific modified aptamers against prostate specific membrane antigen (PSMA) and ERB2 in breast cancer as delivery agents; and (3) Cancer cell obliteration by cell-specific radiation therapy: Boron-Neutron-Capture-Therapy."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Viral RNA
3.	DNA-Directed RNA Polymerases (RNA Polymerase)
4.	RNA (Ribonucleic Acid)
5.	Nucleotides
6.	Boranes
7.	Antigens

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy
2.	Radiotherapy