A-322278

A-322278 is the isopropyl ester prodrug of A 315675

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

1.	Infections 03/15/2006 - "Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection." 02/01/2009 - "A-322278 decreased mortality rates and lung virus titers significantly more than oseltamivir in mice infected with the NA H274Y mutant when therapy was started 4 h before or even 48 h after infection." 03/15/2006 - "We developed an immunocompromised murine model of influenza virus infection and demonstrated comparable efficacy of oral oseltamivir and A-322278 (both given at dosages of 10 mg/kg/day) in reducing viral replication, decreasing weight loss, and prolonging survival. "
2.	Weight Loss (Weight Reduction) 03/15/2006 - "We developed an immunocompromised murine model of influenza virus infection and demonstrated comparable efficacy of oral oseltamivir and A-322278 (both given at dosages of 10 mg/kg/day) in reducing viral replication, decreasing weight loss, and prolonging survival. "
3.	Human Influenza (Influenza) 02/01/2009 - "The new oral neuraminidase (NA) inhibitor A-322278 was evaluated in mice infected with influenza A/H1N1 wild-type virus or the oseltamivir-resistant (H274Y mutant) virus. "

1.	Therapeutics