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5- (6- chloro- 2,4- dioxo- 1,3,4,10- tetrahydro- 2H- 9- oxa- 1,3- diazaanthracen- 10- yl)pyrimidine- 2,4,6- trione

potential antineoplastic agent that induces PTP opening and activates caspase-9 in BCL-2-overexpressing cells; structure in first source

Also Known As:

EM20-25

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Barbiturates: 1074
        5-(6-chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diazaanthracen-10-yl)pyrimidine-2,4,6-trione: 3
  - Pyrans: 130
    - Benzopyrans: 195
      - 5-(6-chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diazaanthracen-10-yl)pyrimidine-2,4,6-trione: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - 5-(6-chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diazaanthracen-10-yl)pyrimidine-2,4,6-trione: 3

Experts

1.	Borgne-Sanchez, Annie: 1 article (03/2010)
2.	Brabant, Magali: 1 article (03/2010)
3.	Buron, Nelly: 1 article (03/2010)
4.	Desgué, Diana: 1 article (03/2010)
5.	Jacotot, Etienne: 1 article (03/2010)
6.	Lassalle, Myriam: 1 article (03/2010)
7.	Porceddu, Mathieu: 1 article (03/2010)
8.	Péchoux, Christine: 1 article (03/2010)
9.	Racoeur, Cindy: 1 article (03/2010)
10.	Rustin, Pierre: 1 article (03/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/12/2010 - "All these tumor cells displayed marked resistance to death caused by apoptotic stimuli like arachidonic acid and the BH3 mimetic EM20-25, which cause cell death through the mitochondrial permeability transition pore (PTP). " 03/31/2010 - "The truncated (t-) Bid protein, synthetic BH3 peptides from Bim and Bak, and the small molecule ABT-737 induced a tumor-specific and OMP-restricted mitochondrio-toxicity, while compounds like HA-14.1, YC-137, Chelerythrine, Gossypol, TW-37 or EM20-25 did not. "
2.	Lymphoma (Lymphomas) 09/01/2008 - "In a direct comparison of peripheral blood mononuclear cells from healthy volunteers with primary CLL, the two agents combined showed a therapeutic index of 19-fold; furthermore, the combination of VSV and EM20-25 increased apoptotic cell death in Karpas-422 and Granta-519 B-lymphoma cell lines (P < 0.005) via the intrinsic mitochondrial pathway. "

Related Drugs and Biologics

1.	BH3 Interacting Domain Death Agonist Protein
2.	Arachidonic Acid (Vitamin F)
3.	Peptides (Polypeptides)
4.	Gossypol
5.	Mitochondrial Permeability Transition Pore
6.	ABT-737
7.	chelerythrine