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PX 916

has antineoplastic activity; structure in first source

Also Known As:

PX-916; PX916 cpd

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxanes
    - PX 916: 1
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - PX 916: 1

Experts

1.	Birmingham, Anne: 1 article (03/2006)
2.	Kirkpatrick, D Lynn: 1 article (03/2006)
3.	Lynch, Stephen M: 1 article (03/2006)
4.	Powis, Garth: 1 article (03/2006)
5.	Wipf, Peter: 1 article (03/2006)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2006 - "PX-916 showed excellent antitumor activity against several animal tumor models with some cures. " 03/01/2006 - "Thus, the study shows that water-soluble inhibitors of thioredoxin reductase-1, such as PX-916, can block thioredoxin-1 signaling in tumors producing marked inhibition of tumor growth." 03/01/2006 - "PX-916 is a potent inhibitor of purified human thioredoxin reductase-1 and of thioredoxin reductase-1 activity in cells and tumor xenografts when given to mice and inhibits the downstream targets of thioredoxin-1 signaling, hypoxia-inducible factor-1alpha, and vascular endothelial growth factor in tumors. "
2.	Hypoxia (Hypoxemia) 03/01/2006 - "PX-916 is a potent inhibitor of purified human thioredoxin reductase-1 and of thioredoxin reductase-1 activity in cells and tumor xenografts when given to mice and inhibits the downstream targets of thioredoxin-1 signaling, hypoxia-inducible factor-1alpha, and vascular endothelial growth factor in tumors. "

Related Drugs and Biologics

1.	Thioredoxins
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)