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rocaglaol

a cytotoxic cyclopenta(b)benzofuran from the bark of Aglaia crassinervia; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - rocaglaol: 4

Experts

1.	Hao, Xiao-Jiang: 1 article (06/2021)
2.	Li, Ya-Nan: 1 article (06/2021)
3.	Li, Yan-Mei: 1 article (06/2021)
4.	Yan, Chen: 1 article (06/2021)
5.	Yang, Hao-Jie: 1 article (06/2021)
6.	Yang, Jue: 1 article (06/2021)
7.	Yi, Ping: 1 article (06/2021)
8.	Yuan, Chun-Mao: 1 article (06/2021)
9.	Zeng, Yan-Rong: 1 article (06/2021)
10.	Aubert, Geneviève: 1 article (08/2009)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2022 - "Isolation and synthesis of rocaglaol derivatives by inhibiting Wnt/β-catenin and MAPK signaling pathways against colorectal cancer." 06/01/2021 - "Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. "
2.	Neoplasms (Cancer) 06/01/2021 - "Six rocaglaol derivatives were isolated from Dysoxylum gotadhora, and those compounds showed good cytotoxic activity with IC50 values ranging from 10 to 350 ng/mL against five different cancer cells. " 06/01/2021 - "Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. " 08/27/2009 - "Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12."
3.	Parkinson Disease (Parkinson's Disease) 05/01/2005 - "A synthetic derivative of the natural product rocaglaol is a potent inhibitor of cytokine-mediated signaling and shows neuroprotective activity in vitro and in animal models of Parkinson's disease and traumatic brain injury."
4.	Leukemia 06/01/2021 - "Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. "
5.	Colonic Neoplasms (Colon Cancer) 06/01/2021 - "Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. "

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