|1.||Kiss, Robert: 5 articles (09/2009 - 02/2006)|
|2.||Mijatovic, Tatjana: 4 articles (09/2009 - 02/2006)|
|3.||Lefranc, Florence: 3 articles (09/2009 - 01/2008)|
|4.||Dicato, Mario: 2 articles (01/2011 - 07/2009)|
|5.||Diederich, Marc: 2 articles (01/2011 - 07/2009)|
|6.||Schumacher, Marc: 2 articles (01/2011 - 07/2009)|
|7.||Juncker, Tom: 2 articles (01/2011 - 07/2009)|
|8.||Mathieu, Véronique: 2 articles (09/2009 - 05/2008)|
|9.||Gailly, Philippe: 2 articles (05/2008 - 01/2008)|
|10.||Dicato, M: 1 article (01/2015)|
01/01/2015 - "UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is effective against various cancer cell types with an excellent differential toxicity. "
01/01/2015 - "By comparing adherent and non-adherent cancer cell types, we validated Mcl-1 as a general and early target of UNBS1450. "
01/01/2008 - "We have investigated the mechanism by which UNBS1450 overcomes the apoptosis resistance of GBMs and determined its anti-tumor effects in comparative studies in vitro in GBM cell viability assays and in vivo using an orthotopic human GBM xenograft model. "
07/01/2009 - "procera and focus more specifically on the anti-cancer activities of UNBS1450 01."
07/01/2009 - "This anti-cancer potential of UNBS1450 01 is achieved by disorganization of the actin cytoskeleton after binding to the sodium pump at the cellular membrane, by inducing autophagy-related cell death, by repressing NF-kappaB activation as well as by down-regulating c-Myc in cancer cells. "
|2.||Prostatic Neoplasms (Prostate Cancer)
05/01/2008 - "The present study indicates that UNBS1450 markedly decreases the in vitro viability/proliferation of human prostate cancer cell lines but not of normal cells. "
05/01/2008 - "Accordingly, the antitumor activity of a novel hemisynthetic cardenolide [1R,3aS,3bR,5aS,6aR,7aS,9R,12aR,13aR,15aR]-3a,11a-dihydroxy-13a-(hydroxymethyl)-9,15a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)icosahydro-1H,4'H-spiro[cyclopenta [7,8]phenanthro[2,3-b]pyrano[3,2-e][1,4]dioxine-11,2'-[1,3]thiazolidin]-4'-one (UNBS1450)] was compared with that of classic cardenolides and reference anticancer agents in prostate cancer cell lines in vitro and in vivo following s.c. "
|3.||Neoplasm Metastasis (Metastasis)
|4.||Melanoma (Melanoma, Malignant)
09/01/2009 - "UNBS1450 also displayed marked anti-tumour activity in the aggressive human metastatic brain melanoma model in vivo. "
09/01/2009 - "The in vivo activity of a novel cardenolide UNBS1450 was evaluated in a melanoma brain metastasis model. "
09/01/2009 - "Furthermore, cardenolides (notably UNBS1450; currently in Phase I clinical trials) displayed marked anti-tumour effects against melanomas in vitro. "
|1.||NF-kappa B (NF-kB)
|3.||Adenosine Triphosphate (ATP)
|4.||Ouabain (G Strophanthin)
|6.||Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)
|7.||Adenosine Triphosphatases (ATPase)
|1.||Heterologous Transplantation (Xenotransplantation)