|1.||Khalafalla, Mahmoud G: 1 article (01/2015)|
|2.||Weisman, Gary A: 1 article (01/2015)|
|3.||Woods, Lucas T: 1 article (01/2015)|
|4.||Camden, Jean M: 1 article (01/2015)|
|5.||Erb, Laurie: 1 article (01/2015)|
|6.||El-Sayed, Farid G: 1 article (01/2015)|
|7.||Petris, Michael J: 1 article (01/2015)|
|8.||Waghabi, Mariana C: 1 article (01/2012)|
|9.||Araújo-Jorge, Tania C: 1 article (01/2012)|
|10.||Feige, Jean-Jacques: 1 article (01/2012)|
03/01/2008 - "Our study shows that GW788388 is a potent and selective inhibitor of TGF-beta signalling in vitro and renal fibrosis in vivo."
01/01/2012 - "Interestingly, we further demonstrated that administration of GW788388 at the end of the acute phase (20 dpi) still significantly increased survival and decreased cardiac fibrosis (evaluated by Masson's trichrome staining and collagen type I expression), in a stage when parasite growth is no more central to this event. "
03/01/2008 - "Using db/db mice, which develop diabetic nephropathy, we found that GW788388 given orally for 5 weeks significantly reduced renal fibrosis and decreased the mRNA levels of key mediators of extracellular matrix deposition in kidneys. "
03/01/2010 - "In the bleomycin-induced fibrosis model, treatment with GW788388 and bosentan prevented the fibrotic response. "
01/01/2012 - "Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease."
05/01/2010 - "In brief, treatment with a novel TGF-beta type I receptor inhibitor, GW788388, significantly reduced TGF-beta activity, leading to the attenuation of systolic dysfunction and left ventricular remodeling in an experimental rat model of MI."
05/01/2010 - "We thus aimed to inhibit TGF-beta signaling using a novel orally active TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)] inhibitor (GW788388) to attenuate left ventricular remodeling and cardiac dysfunction in a rat model of MI. "
|3.||Chagas Disease (American Trypanosomiasis)
|4.||Diabetic Nephropathies (Diabetic Nephropathy)
|1.||Transforming Growth Factor beta (TGF-beta)
|2.||Collagen Type I (Type I Collagen)
|3.||Messenger RNA (mRNA)
|8.||4- (5- benzo(1,3)dioxol- 5- yl- 4- pyridin- 2- yl- 1H- imidazol- 2- yl)benzamide
|9.||TGF-beta type I receptor